摘要
目的 :探讨潘妥拉唑 (PAN)及奥美拉唑 (OME)对健康人 2 4h胃内 p H的影响。 方法 :2 8例健康志愿者随机分为 3组。其中 PAN组 10例 ,OME组 8例 ,分别静脉滴注 PAN 80 m g,OME 80 m g,1次 / d,连续 2 d,第 2天给药后进行胃内 p H 2 4h监测 ;对照组 10例 ,直接进行胃内 p H 2 4h监测。结果 :PAN及 OME均能明显提高 2 4h胃内 p H平均值、p H >4总时间百分比及 2 4h胃内 p H变化曲线下面积 (P<0 .0 1) ;用药后 2 4h,每 1h胃内 p H均明显升高 (P<0 .0 1)。与 OME比 ,PAN能更显著地提高 2 4h胃内 p H平均值 (P<0 .0 5 )及 2 4h胃内 p H变化曲线下面积 (P<0 .0 1) ;2 4h中有 13h胃内 p H值升高更明显 (P<0 .0 5 )。 结论 :PAN及 OME均有较强的抑制胃酸分泌作用 ,前者作用更强。
Objective: To investigate the effects of pantoprazol and omeprazol on 24 h intragastric pH in healthy human subjects. Methods: Twenty eight healthy volunteers were randomized into 3 groups. Ten subjects in pantoprazol group received 80 mg pantoprazol intravenously for 2 days and received 24 h intragastric pH monitoring in the second day. Eight subjects in omeprazol group received 80 mg omeprazol intravenously for 2 days and had 24 h intragastric pH monitoring in the same way. The other 10 subjects were in control group and 24 h intragastric pH monitoring were carried out directly. Results: Both pantoprazol and omeprazol could greatly increase the 24 h intragastric mean pH, the total percentage time of intragastric pH>4 and the area under the curve of intragastric pH ( P <0.01). Every hour during 24 h after drug administration, the intragastric pH was also greatly increased ( P <0.01). Compared with omeprazol, pantoprazol had more significant effect on increasing the 24 h mean pH ( P <0.05) and the area under the curve of intragastric pH ( P <0.01). There were 13 hours in one day after drug administration, the intragastric pH were even higher in pantoprazol group than in omeprazol group ( P <0.05). Conclusion: Both pantoprazol and omeprazol have great inhibitory effect on gastric acid secretion, but the effect of the former is stronger.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2000年第2期159-161,共3页
Academic Journal of Second Military Medical University
基金
上海市青年科技启明星计划资助!99QB14 0 45
