摘要
目的 :研究胎盘和蜕膜中促 (抑 )凋亡基因 Bax/Bcl- 2表达及其在重度妊高征发生、发展中的作用。方法 :对 40例正常晚孕和 40例重度妊高征病例的胎盘和蜕膜组织进行分析 :用免疫组织化学方法 (S- P法 )检则促 (抑 )凋亡基因Bax/Bcl- 2表达水平。结果 :正常晚孕组胎盘和蜕膜 Bax分别是 2 8.95 %± 9.6 7% ,42 .2 1%± 4.70 % ;Bcl- 2分别是 2 2 .91%± 7.6 9% ,43.15 %± 9.18% ;Bax/Bcl- 2分别是 1.2 0 ,0 .98;重度妊高征组胎盘和蜕膜 Bax分别是 42 .46 %±11.70 % ,6 0 .0 4%± 13.79% ,比正常晚孕显著增高 (P<0 .0 1) ;Bc1- 2分别是 2 2 .34 %± 7.78% ,33.91± 6 .46 % ,比正常晚孕增高 (P<0 .0 5 ) ;Bax/Bcl- 2分别是 2 .90 ,2 .38,正常晚孕组中 Bax/Bcl- 2表达平衡 ,而重度妊高征组中这种平衡关系被打破。结论 :正常晚孕组和重度妊高征组中都有一定量的 Bax、Bcl- 2表达 ;重度妊高征组中 ,这种表达增强 ;Bax/Bcl- 2表达间的平衡决定胎盘蜕膜的命运 。
Objective: to investigate Bax and Bcl 2 genetic expression in serious pregnancy induced hypertension(SPIH) Methods:40 cases of normal term pregnancy(NTP) and 40 cases of SPIH were examined.Bax and Bcl 2 were detected by immunohistochemical staining(S P).Results:In NTP each index in placenta and decidua were: Bax was 28.95%±9.67%,42.21%±4.70%;Bcl 2 was 22.91%±7.69%,43.15%±9.18%;Bax/Bcl 2 was 1.20,0.98;In SPIH,Bax was 42.46%±11.70%,60.04%±13.79%,it is higher significantly than in NTP( P <0.01);Bcl 2 was 23.34%±7.78%,33.91%±6.46%, it is higher significantly than in NTPCP( P <0.05); Bax/Bcl 2 was 2.90,2.38,it is balance in NTP,while the balance is broken in SPIH.Conclusions:Bax and Bcl 2 were detected quantitative in placenta and decidua of NTP & SPIH,and they are more significant in SPIH;The balance of Bax/Bcl 2 decides the fate of placenta and decidua,and it effects the output of pregnancy furtherly.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2000年第2期94-96,共3页
Journal of Practical Obstetrics and Gynecology
