摘要
鼻型结外NK／T细胞淋巴瘤是中国常见的非霍奇金淋巴瘤，其诊断和治疗仍存在不少难题。根据典型的组织学表现和CD3E、CD56、EBER＋可确定诊断，同时需检查与预后相关的指标。建议在正电子发射计算机断层显像．电子计算机x射线断层扫描技术（PET—CT）检查基础上仍采用AnnArbor分期系统。早期患者宜化疗＋放疗，晚期患者建议联合化疗，化疗可采用含有左旋门冬酰胺酶的方案。对造血干细胞移植应持积极态度，新治疗方案应在大样本随机对照研究中评价。
Extranodal NK/T cell lymphoma, nasal type is a common subtype of non-Hodgkin＇s lymphomas in China, Many difficulties remain in its diagnosis and treatment. Correct diagnosis can be established according to the typical histology findings and immunology phenotypes with CD3~, EBER and/or CD56 positive, Prognostic factors should be assessed in the initiation of diagnosis. Ann Arbor staging classification has still being widely used and PET-CT scan is strongly recommended. Chemotherapy followed by radiotherapy should been considered for early-stage patients and combined chemotherapy is the best choice for advanced stage patients. The regimens containing L-asparaginase should be considered firstly due to the evidences from many clinical trials. Stem cell transplantation is recommended to almost all patients except for IE stage patients without any unfavorable prognostic factor. New regimens should be investigated and assessed in the perspective randomized clinical trials.
出处
《白血病．淋巴瘤》
CAS
2012年第11期643-645,共3页
Journal of Leukemia & Lymphoma
