摘要
目的:观察持续血液滤过治疗重症急性胰腺炎的临床疗效。方法:将84例重症急性胰腺炎患者随机分为治疗组和对照组各42例。对照组予以常规治疗,包括禁食水、持续胃肠减压;胃肠外营养,抗生素治疗;抑制胃酸分泌,抑制胰酶活性;维持体内水电解质和酸碱平衡;控制并发症进展;必要时应用止痛药。治疗组在对照组治疗基础上予以持续血液滤过治疗。结果:治疗组总有效率90.48%,对照组总有效率71.43%,两组总有效率比较差异有统计学意义(P<0.05)。两组患者治疗后血清淀粉酶、尿淀粉酶变化明显改善,与治疗前比较比较差异有显著性(P<0.01);两组患者治疗后,治疗组血清淀粉酶、尿淀粉酶改善优于对照组,两组比较差异有统计学意义(P<0.01)。治疗后治疗组血肌酐(SCr)、碱性磷酸酶(APS)、血清总胆红素(TB)、谷丙转氨酶(ALT)、C反应蛋白(CRP)、APACHEII评分改善优于对照组,两组比较差异有统计学意义(P<0.01)。结论:重症急性胰腺炎在常规内科治疗基础上予以持续血液滤过能够有效缓解病情,提高临床疗效。
Objective：To observe the clinical effect of continuous hemofiltration（CHF） in treating sever acute pancreatitis（SAP）.Methods：84 SAP patients were randomly divided into the treatment group and the control group with 42 cases in each group.The control group was given routine treatment,including no drinking or eating,continuous gastrointestinal decompression;parenteral nutrition,antibiotic treatment;inhibition of gastric acid secretion and pancreatic enzyme activity;keeping water and electrolyte and sour alkali balanced;control of complication progress;use of painkiller when necessary.Based on the treatment in the control group,the treatment group was given CHF additionally.Results：The total effective rate in the treatment group and the control group was 90.48% and 71.43%respectively,and there was significant difference（P0.05）.After treatment,the serum amylase and urine amylase in the treatment group were significantly improved than that in the control group（P0.01）;and also the SCr,APS,TB,ALT,CRP,and APACHEII scoring were significantly improved in the treatment group than that in the control group（P0.01）.Conclusion：Routine medical therapy combined additional CHF in SAP patients can effectively alleviate the illness and increase the clinical effect.
出处
《中国医药导刊》
2012年第10期1691-1692,1694,共3页
Chinese Journal of Medicinal Guide
关键词
急性胰腺炎
血液滤过
C反应蛋白
Sever acute pancreatitis（SAP）
Hemofiltration
C-reactive peptide（CRP）
