摘要
目的 :探讨内毒素 (LPS)及肿瘤坏死因子 (TNF)在重型脑外伤后多器官功能障碍综合征 (MODS)发生发展中的作用与机制及临床意义。方法 :应用动态浊度法及放免法动态监测68例严重颅脑外伤患者血浆LPS及TNF的水平变化 ,观察其与MODS发生的关系。结果 :68例患者血浆LPS及TNF水平较正常对照组明显升高 (P<0.01)。结论:重型颅脑损伤后导致的血浆高水平LPS与TNF参与了MODS的发病过程 ,是影响预后的重要因素之一。
Objective: To investigate the effect and prognosis of serum endotoxin and tumor necrosis factor (TNF) during the occurence and development of multi-organ dysfunction syndrome(MODS) in serious brain injury cases. Methods:The concentration changes of serum endotoxin and TNF in 68 patients with serious brain injury were detected dynamically,To investigate the relationship occurence of MODS with it.Results: The serum endotoxin and TNF concentrations were raised obviously in all 68 cases, and there was obvious difference between them and normal contrast(P< 0.01).Conclusion:High serum level of LPS and TNF take part in the occurrence of MODS following serious brain injury,and is one of the important factors that affect the prognosis.
出处
《现代康复》
CSCD
2000年第6期850-851,共2页
Modern Rehabilitation
基金
贵州省科学基金资助!(993010)
