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脂肪因子网膜素生物学特性的研究进展 被引量：1

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摘要 网膜素（omentin）是由美国马里兰大学Yang等于2003年首先发现的特异性表达于网膜脂肪组织的细胞因子，近年来发现它与脂肪组织分泌的其他细胞因子如瘦素、脂联素和内脂素等共同参与了糖代谢及血管内皮功能调节。同时网膜素与肥胖、2型糖尿病、动脉粥样硬化及炎症密切相关，在这些疾病发病机制中的作用也备受关注。笔者就网膜素生物学特性的研究进展作一简介。
作者 胡振平 邓华聪 瞿华
机构地区 重庆医科大学附属第一医院内分泌科m
出处 《中华糖尿病杂志》 CAS 2012年第11期652-654,共3页 CHINESE JOURNAL OF DIABETES MELLITUS
基金 国家自然科学基金项目（81070639,30771038）
关键词 生物学特性 脂肪因子 动脉粥样硬化 细胞因子 脂肪组织 特异性表达 马里兰大学 2型糖尿病
分类号 R363 [医药卫生—病理学]
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  • 3Schaffler A, Neumeier M, Herfarth H, et al. Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta, 2005, 1732: 96-102.
  • 4Yang RZ, Lee M J, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab, 2006, 290 : 1253-1261.
  • 5de Souza Batista CM, Yang RZ, Lee MZ, et al.Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 2007, 56. 1655-1661.
  • 6Looker HC, Knowler WC, Hanson RL, et al. Changes in BMI and weight before and after the development of type 2 diabetes. Diabetes Care, 2001,24: 1917-1922.
  • 7Trayhurn P, Beattie JH. Physiological role of adipose tissues : white adipose tissues as an endocrine and secretory organ. Proc Nutr Soc, 2001, 60: 329-339.
  • 8Schaffler A, Neumeier M, Herfarth H, et al Genomie structure of human omentin, a new adipocytokine expressed in omental adipose tissue. Biochim Biophys Acta, 2005, 1732: 96-102.
  • 9Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab, 2006, 290: 1253-1261.
  • 10de Souza Batista CM, Yang RZ, Lee MZ, et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes, 2007, 56: 1655-1661.

共引文献83

同被引文献13

  • 1黄秋生,黄茂,苏梅,张希龙,贾恩志,殷凯生.探讨成年男性阻塞性睡眠呼吸暂停综合征患者血清脂联素水平[J].南京医科大学学报（自然科学版）,2004,24(6):650-653. 被引量：8
  • 2Babu AR,Herdegen J,Fogelfeld L,et al.Type 2 diabetes,glycemic control,and continuous positive airway pressure in obstructive sleep apnea[J].Arch Intern Med,2005,165(4):447-452.
  • 3Kurt OK,Tosun M,Alcelik A,et al.Serum omentin levels in patients with obstructive sleep apnea[J].Sleep Breath,2014,18(2):391-395.
  • 4Wang Q,Feng X,Zhou C,et al.Decreased levels of serum omentin-1in patients with obstructive sleep apnoea syndrome[J].Ann Clin Biochem,2013,50(Pt 3):230-235.
  • 5Harsch IA,Schahin SP,Radespiel-Trger M,et al.Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome[J].Am J Respir Crit Care Med,2004,169(2):156-162.
  • 6Furukawa S,Fujita T,Shimabukuro M,et al.Increased oxidative stress in obesity and its impact on metabolic syndrome[J].J Clin Invest,2004,114(12):1752-1761.
  • 7Yang RZ,Lee MJ,Hu H,et al.Identification of omentin as a novel depot-specific adipokine in human adipose tissue:possible role in modulating insulin action[J].Am J Physiol Endocrinol Metab,2006,290(6):1253-1261.
  • 8Yamawaki H,Kurarnoto J,Kameshima S,et al.Omentin,a novel adipecytokine inhibits TNF-induced vascular inflammation in human endothelial cells[J].Biochem Biophys Res Commun,2011,408(2):339-343.
  • 9Yamawaki H,Tsubaki N,Mukohda M,et al.Omentin,a novel adipokine,induces vasodilatation in rat isolated blood vessels[J].Biochem Biophys Res Commun,2010,393(4):668-672.
  • 10陈列,王玮.合并2型糖尿病的阻塞性睡眠呼吸暂停综合征患者血管活性物质的变化[J].国际呼吸杂志,2011,31(17):1309-1314. 被引量：2

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中华糖尿病杂志
2012年 第11期

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