摘要
目的观察联合应用巴氯芬、替扎尼定和乙哌立松治疗脊髓损伤中重度痉挛患者的临床效果。方法住院脊髓损伤中重度痉挛患者18例,采用2种或3种药物联合应用,所有患者连续服药2个月,并随访4个月以上。采用改良Ashworth评分进行评定,同时观察痉挛缓解持续时间及血压、血尿常规和肝肾功能。结果重度痉挛患者16例中,3例改良Ashworth评分降低3级,12例降低2级,1例降低1级,伴神经痛明显减轻;2例中度痉挛患者均降低1级,伴神经痛明显减轻。服药后肝肾功能未见异常,出现轻度嗜睡2例。结论联合用药对脊髓损伤中重度痉挛患者的解痉效果明显,副作用小。
Objective To investigate the effect of combination of baclofen, tizanidine and eperisone on moderate or severe spasticity after spinal cord injury. Methods 18 inpatients with moderate （n=2） or severe （n=1 6） spasticity after spinal cord injury were treated with combination of 2 or 3 kinds of drugs for 2 months, and followed up for at least 4 months with modified Ashworth scale （MAS）. Their blood pressure, blood and urine routine, liver and kidney function were observed. Results Among the 16 cases of severe spasticity （MAS ≥ 3）, MAS reduced 3 grades in 3 cases, 2 grades in 12 cases, 1 grade in 1 case, with alleviation of phantom pain. For the cases of moderate spasticity （MAS=2）, the MAS reduced 1 grade with alleviation of phantom pain. Slightly drowsiness was observed in 2 cases. No hepatic or renal dysfunctions was found. Conclusion Combination ofbaclofen, tizanidine and eperisone is effective on moderate or severe spasticity after spinal cord injury with limited side-effects.
出处
《中国康复理论与实践》
CSCD
北大核心
2012年第11期1080-1081,共2页
Chinese Journal of Rehabilitation Theory and Practice
基金
中国康复研究中心科研基金资助项目(2009-2)
关键词
脊髓损伤
痉挛
巴氯芬
替扎尼定
乙哌立松
康复
spinal cord injury
spasticity
baclofen
tizanidine
eperisone
rehabilitation
