摘要
目的探讨儿童腹型过敏性紫癜的有效治疗方法。方法回顾性分析54例腹型过敏性紫癜患儿的临床资料，并按治疗方法的不同分为三组：I组、Ⅱ组、Ⅲ组各18例，在常规治疗基础上，I组应用大剂量甲泼尼龙治疗，Ⅱ组应用雷尼替丁治疗，Ⅲ组应用西咪替丁治疗，分析三组疗效及不良反应等。结果I组、Ⅱ组皮疹消失时间、粪潜血阴性时间、腹痛消失时间等均明显短于Ⅲ组（t=11．775、8．901、7．613、5．786、10．105、12．347，均P〈0．05），I组与Ⅱ组间差异均无统计学意义（均P〉0．05）。I组不良反应发生率明显高于Ⅱ组和Ⅲ组（X^2=4．500、5．017，均P〈0．05）。结论甲泼尼龙治疗儿童腹型过敏性紫癜疗效明显，但不良度府发毕率掩高．
Objective To explore the effective treatment in children of abdominal allergicpurpura. Methods To retrospectively analyze the clinical data of 54 children with abdominal allergicpurpura. 54 cases were divided into three groups. Each 18 cases in group I ,group Ⅱ and group Ⅲ. It was used large doses of methylpred- nisolone in the group I ,ranitidine in the group Ⅱ and cimetidine in the group Ⅲ based on conventional treatment. To analyze the effect and adverse effect after the treatment. Results The effect of group I and group Ⅱ was significantly higher than group Ⅱ（t = 11. 775,8. 901,7. 613,5. 786,10. 105,12. 347 ,all P 〈0.05）. There was no significant difference between group I and group Ⅱ （P 〉 0.05）. The adverse effect of group I was significantly higher than the other groups （ X2 = 4.500,5. 017, all P 〈 0.05 ）. Conclusion The treatment of hormone had obvious effect in children with abdominal allergicpurpura, but it had some risks in the gastrointestinal, so we should close observe the gastrointestinal tract in children. Ranitidine and cimetidine are the drugs of inhibiting gastric acid secretion, but the ranitidine much better than eimetidine.
出处
《中国基层医药》
CAS
2012年第24期3729-3730,共2页
Chinese Journal of Primary Medicine and Pharmacy
