摘要
目的观察动脉粥样硬化性血栓性脑梗死患者采用培哚普利联合阿托伐他汀治疗的疗效及安全性。方法将62例动脉粥样硬化性血栓性脑梗死患者随机分为联合组(32例)及单药组(30例),两组均采取常规抗凝、溶栓治疗,单药组在此基础上给予培哚普利4 mg/d单药治疗,联合组在对照组基础上加服阿托伐他汀10 mg/d。治疗12周后,比较两组血压、血脂、IMT及神经功能缺损评分的变化。结果联合组治疗12周后,总胆固醇、LDL-C、IMT降幅及HDL-C的升幅均显著高于单药组(P<0.05);两组神经功能缺损及血压降幅改变无显著差异。结论相对于单用培哚普利,联合阿托伐他汀能有效降低动脉粥样硬化性血栓性脑梗患者的血压与血脂水平,但对于神经功能的改善不明显。
【Objective】To observe the efficacy and safety by the use of perindopril combined with atorvastatin in treatment of patients with atherosclerotic cerebral infarction 【Methods】62 patients were divided into 2 groups,both of them are treated with anticoagulation and thrombolysis.A group intake perindopril 4 mg/d,B group intake atorvastatin 10 mg/d.the blood pressure,serum lipid and neurological functional deficit scales were observed after 12 weeks.【Resluts】The decreasing amplitude of total cholesterol LDL-C and IMT of A group is significantly lower than B group,when the increasing amplitude of HDL-C of Agroup is significantly higher than B group（P0.05）,there were no significant difference of blood pressure and neurological functional deficit scales between two groups.【Conclusion】 The use of perindopril combined with atorvastatin treatment provides a superior blood pressure and serum lipid control compared with perindopril,there were no significant improvement of neurological functional in two groups.
出处
《中国医学工程》
2012年第10期19-20,22,共3页
China Medical Engineering
关键词
培哚普利
阿托伐他汀
动脉粥样硬化
血栓
脑梗死
疗效
Perindopril
Atorvastatin
atherosclerosis
thrombus
cerebral infarction
clinical effect
