摘要
目的:研究讨探新辅助化疗对乳腺癌患者组织雌激素受体表达的影响。方法:104例患者均均采用AC方案:环磷酰胺(CTX)600mg/m2静脉注射;表阿霉素(Epirubicin)100mg/m2。化疗前后均行ER检查,对比结果。结果:新辅助化疗前、后ER表达的阳性率为49%和52%。化疗前49例患者ER表达阳性,14例化疗后转阴;51例患者化疗前ER表达阴性,17例换料后转为阳性,前后构成比发生了显著的变化(P=0.0001)。新辅助化疗后,有4例患者完全缓解,74例患者部分缓解,20例患者稳定,6例患者进展,总有效率75%。结论:新辅助化疗确实对ER的表达产生了影响,它可以增加ER的表达,可以根据ER表达情况对患者的预后进行评估。
Objective：To study the effects on breast cancer estrogen receptor expression by neoadjuvant chemotherapy.Methods：104 cases were all adopt AC plan：cyclophosphamide（CTX） 600 mg/m2 intravenous;Table adriamycin Epirubicin） 100 mg/m2.Chemotherapy were performed before and after ER check,compared to the results.Results：New adjuvant chemotherapy before and after the expression of telomerase ER 49% and 52%.Chemotherapy 49 patients before ER express positive,and 14 cases after chemotherapy shade;51 patients before chemotherapy ER express negative,17 cases to the refueling positive,than before and after a notable changes have taken place（P=0.0001）.New adjuvant chemotherapy,the total effective rate of 75%.Conclusion：Neoadjuvant chemotherapy for the expression of really ER the influence,it can increase the ER of expression,can according to the ER expression of the patient＇s prognosis for the evaluation.
出处
《中国医药导刊》
2012年第11期1881-1881,1883,共2页
Chinese Journal of Medicinal Guide
关键词
乳腺癌
新辅助化疗
雌激素受体
Breast cancer
New adjuvant chemotherapy
Estrogen receptor
