摘要
目的探讨吲哚胺2,3双加氧酶(IDO)与胃癌免疫逃逸关系的研究现状及发展趋势。方法回顾性分析近10年来国内、外有关IDO、胃癌免疫逃逸以及二者之间的关系的相关文献。结果胃癌通过CD4+CD8+等调节性T细胞诱导树突状细胞IDO的表达,使得其所处的微环境出现"色氨酸饥饿",从而抑制T细胞增殖;同时,色氨酸代谢产物对T细胞亦存在细胞毒性作用,抑制T细胞的增殖。IDO特异性抑制剂1-MT与化疗药物结合起来在胃癌的治疗上有协同作用。结论 IDO作为免疫调节酶可能在胃癌诱导机体产生免疫耐受过程中起着关键性作用,其可能成为抑制胃恶性肿瘤形成和提高肿瘤免疫治疗效果的新靶点。
Objective To explore the research status and development tendency of relation between indoleamine 2,3-dioxygenase（IDO）and immune escape of gastric cancer.Methods The related literatures about IDO,immune escape of gastric cancer,and their the relationship at domestic and international in recent ten years were collected and reviewed.Results Gastric cancers induced that dendritic cells expressed IDO by the CD4＋ CD8＋ regulatory T cells,which made the microenviroment tryptophan starvation,thus inhibited T cell proliferation.While tryptophan metabolites existed T cell cytotoxicity that inhibited T cell proliferation.IDO-specific inhibitor 1-MT combinated with chemotherapy drugs in the treatment for gastric cancer was a synergistic effect.Conclusions IDO as an immune modulating enzymes may play a key role in the process of immune tolerance that induced by gastric body.IDO may become a new target for inhibition of gastric malignancy formation and enhance the effectiveness of tumor immune treatment.
出处
《中国普外基础与临床杂志》
CAS
2012年第11期1255-1259,共5页
Chinese Journal of Bases and Clinics In General Surgery
关键词
胃癌
吲哚胺2
3双加氧酶
免疫逃逸
免疫治疗
Gastric cancer
Indoleamine 2
3-dioxygenase
Immune escape
Immune therapy
