摘要
目的了解西藏林芝地区健康人群乙脑、登革热、森林脑炎和肾综合征出血热抗体水平,为林芝地区的虫媒传染病的诊断和防控提供参考依据。方法 2010年7—8月,根据既往已证实存在疟疾病本地流行等经验,选择海拔2 000 m以下的墨脱县达木乡、背崩乡、墨脱镇和察隅县下察隅镇为调查区域,调查对象为在调查时段在家中的当地常住居民。采集不同年龄段健康人群血清样本。用间接ELISA法对上述调查对象血清样本进行乙脑、登革热、森林脑炎和肾综合征出血热IgG抗体的检测。结果共采集并完成了350份(其中墨脱县249份,察隅县101份)血清标本的检测,乙脑、登革热、森林脑炎和肾综合征出血热的阳性标本数分别为27、6、12和2份,阳性率分别为7.71%(27/350)、1.71%(6/350)、3.43%(12/350)和0.57%(2/350)。察隅县森林脑炎阳性率高于墨脱县,分别为6.93%(7/101)和2.00%(5/249)(P<0.05);海拔≤1 500 m与>1 500 m地区的人群森林脑炎病毒阳性率分别为1.97%(5/254)和7.29%(7/96),两者差别有统计学意义(P<0.05),且随着海拔增高,阳性率升高;森林脑炎病毒抗体阳性率在不同年龄组间差别有统计学意义(P<0.05),其中11～50岁年龄组的阳性率最高,达5.88%(11/187),≤10、>50岁年龄组的阳性率均为0。结论林芝地区存在乙脑和森林脑炎病毒的自然疫源地的可能性极大,尚不确定存在登革热和肾综合征出血热传染病的可能。
Objective To investigate IgG antibody against Japanese encephalitis virus, dengue vi-rus, tick-borne encephalitis virus and hantaan virus among population in Linzhi area of Tibet, and provide serologic evidence for diagnosis, prevention and control of arthropod-borne infectious diseases. Methods Blood samples were collected from residents living at an altitude of ≤ 2 000m and different age groups in Zayu （Zayu town） and Medog （Damu, Beibong, and Medog towns） counties which had been identified as malaria epidemic area during July to August 2010. All samples were tested by indirect ELISA for IgG anti-body. Results A total of 350 blood samples were collected, of which 249 and 101 were from Medog and Zayu respectively. 7.71% （27/350）, 1.71% （6/350）, 3.43% （12/350）, and 0.57% （2/350） of samples were positive for Japanese encephalitis virus, dengue virus, tick-borne encephalitis virus, and hantaan virus, respectively. The positive ratio for tick-borne encephalitis virus was 6. 93% （7/101） in Zayu and 2.00% （5/249）in Medog （P 〈0.05）, 1.97% （5/254） at an altitude of ≤1 500 m and 7.29% （7/96） at an altitude of 〉 1 500 m （ P 〈 0. 05 ）, and increased with increasing altitude. A significant pos-itive ratio for tick-borne encephalitis virus antibody was analyzed among different age groups. 11 to 50 years age group of them was highest （5. 88% ）（11/187）, followed by ≤ 10 （0%） and 〉 50 years age groups （0%）. Conclusion Infections by Japanese encephalitis virus and tick-borne encephalitis virus were con-finned in Linzhi, but more lab evidence will be provided for confirmation of Dengue fever and Hemorrhagic fever with renal syndrome in Linzhi.
出处
《华南预防医学》
2012年第6期16-20,共5页
South China Journal of Preventive Medicine
基金
广东省疾病预防控制中心的大力支持
关键词
乙脑
登革热
森林脑炎
肾综合征出血热
虫媒病毒
Japanese encephalitis
Dengue fever
Tick-borne encephalitis
Hemorrhagic fe-ver with renal syndrome
Arboviruses
