摘要
目的:综合评价国内呼吸机相关性肺炎(ventilator associated pneumonia,VAP)发病的危险因素。方法:通过国内外数据库检索中国发表的VAP危险因素的相关研究,用Meta分析的方法对入选文献进行定量综合分析;用固定效应模型或随机效应模型计算OR值及95%CI。结果:总共14篇相关文献入选本研究,累计病例691例,对照病例1 145例;在分析的9个危险因素中有5个因素差异具有统计学意义,与VAP相关的危险因素及其OR值分别为:预防性抗菌药物使用(OR=6.60,95%CI:3.01～14.50)、气管切开(OR=4.25,95%CI:2.32～7.76)、鼻胃管留置(OR=3.09,95%CI:1.85～5.16)、胃肠内营养(OR=3.44,95%CI:1.22～9.68)、糖皮质激素应用(OR=3.28,95%CI:1.68～6.38)。结论:应针对国内VAP发病相关的危险因素采取针对性预防措施,从而降低VAP的发生率。
Objective：To synthetically evaluate the risk factors of ventilator associated pneumonia （VAP） in China. Methods：The relative researches of VPA were searched by domestic and abroad literature database, and literatures published in China selected were quantitatively analyzed by Meta-analysis. The pooled OR and its corresponding 95% CI were calculated by fixed effect model or random effect model. Results： Fourteen relative literatures were selected in this study,including 691 patients and 1 145 controls. Among nine risk factors, five factors had statistical significances. Risk factors of VAP and its value of OR were as follows：prophylactic antibiotic use （ OR =6.60,95% CI ： 3.01 N 14.50）, tracheostomy （ OR =4.25,95% CI ： 2.32 N7.76）, nasal and gastric tube （ OR =3.09,95% CI ： 1.85 -5.16）, enteral nutrition （OR =3.44,95% CI ： 1.22 -9.68）, glucocorticoid use （ OR =3.28,95% CI： 1.68 ~6.38）. Conclusion： Special methods should be taken, according to the risk factors of VAP, to decrease the incidence rate of VAP in China.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2012年第11期1621-1625,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏高校优势学科建设工程资助(JX10231801)
