摘要
目的:揭示急性阑尾炎患者血浆β-防御素-3浓度的变化,探讨其与急性阑尾炎患病危险性的相关性。方法:收集急性阑尾炎患者作为阑尾炎组,共100例。收集同期健康体检者作为对照组,共100例。ELISA检测血浆β-防御素-3浓度。统计分析其与急性阑尾炎患病危险性的相关性。结果:阑尾炎组血浆β-防御素-3浓度(80.1±32.4)pg/ml显著低于对照组(151.3±27.0)pg/ml(P<0.01)。Logistic回归分析显示,血浆β-防御素-3浓度(OR=0.492,95%CI=0.211～0.843,P<0.01)是罹患急性阑尾炎的独立危险因素。ROC曲线分析显示,血浆β-防御素-3浓度预测罹患急性阑尾炎有显著预测价值(曲线下面积=0.824,95%CI=0.769～0.874,P<0.01),且判定血浆β-防御素-3浓度<121.4 pg/mL,对预测罹患急性阑尾炎有83.0%的灵敏度和78.0%特异度。结论:急性阑尾炎患者血浆β-防御素-3水平降低,可能是急性阑尾炎发病的危险因素。
Objective In this study,change of plasma beta-defensin-3 level was determined in patients with acute appendicitis and its correlation with disease was evaluated.Methods 100 consecutive patients with acute appendicitis and 100 healthy controls were enrolled into this study.Plasma beta-defensin-3 concentration was measured by ELISA.Its correlation with disease was analyzed statistically.Results The plasma beta-defensin-3 level（80.1±32.4 pg/ml） in patients was significantly lower than that（151.3±27.0 pg/ml） in healthy controls（P0.01）.On a multivariate logistic regression,plasma beta-defensin-3 level（OR=0.492,95%CI=0.211~0.843,P0.01） was an independent risk factor predicting acute appendicitis.A receiver operating characteristic curve identified that a plasma beta-defensin-3 level 121.4 pg/ml predicted acute appendicitis with 83.0% sensitivity and 78.0% specificity（area under curve =0.824,95%CI=0.769~0.874,P0.01） respectively.Conclusion Decreased beta-defensin-3 is found after acute appendicitis and low beta-defensin-3 may be the risk factor independently associated with acute appendicitis.
出处
《放射免疫学杂志》
CAS
2012年第6期665-666,共2页
Journal of Radioimmanology
