摘要
目的:认识慢性牙周炎患者血浆穿透素-3(PTX-3)浓度的变化并分析其临床意义。方法:收集慢性牙周炎患者作为牙周炎组,共80例。收集同期牙周健康者作为对照组,共80例。ELISA检测血浆PTX-3浓度,进行统计分析。结果:牙周炎组血浆PTX-3浓度(3.4±1.5)ng/ml显著高于对照组(1.8±0.6)ng/ml(P<0.001)。经Pearson相关分析,牙周炎组血浆PTX-3浓度与牙周探诊深度(r=0.376,P<0.01)、附着丧失(r=0.426,P<0.01)和出血指数(r=0.401,P<0.01)呈显著正相关。Logistic回归分析显示,血浆PTX-3浓度(OR=1.791,95%CI=1.172～5.814,P<0.01)是慢性牙周炎发生的独立危险因素。ROC曲线分析显示,血浆PTX-3浓度对慢性牙周炎发生有显著预测价值(曲线下面积=0.834,95%CI=0.764～0.905,P<0.001),且判定血浆PTX-3浓度>2.8ng/ml,对预测慢性牙周炎发生有81.3%的灵敏度和75.0%的特异度。结论:慢性牙周炎患者血浆PTX-3水平升高,PTX-3可能参与慢性牙周炎的病理生理过程。
Objective In this study,to realize the changes of plasma pentraxin-3 level in patients with chronic periodontitis and its clinical significance was analyzed.Methods 80 consecutive patients with chronic periodontitis and 80 healthy controls were enrolled into this study.Plasma pentraxin-3 concentration was measured by ELISA and statistical analysis was taken.Results The plasma pentraxin-3 level（3.4 1.5 ng/ml） in patients was significantly higher than that（1.8±0.6 ng/ml） in healthy controls using t test（P0.001）.Pearson correlation coefficient showed that probing depth（r=0.376,P0.01）,attachment loss（r=0.426,P0.01） and bleeding index（r=0.401,P0.01） were positively related to plasma pentraxin-3 level in the patients with chronic periodontitis.On a multivariate logistic regression,plasma pentraxin-3 level（OR=1.791,95%CI=1.172~5.814,P0.01） was an independent risky factor.A receiver operating characteristic curve identified that a plasma pentraxin-3 level 2.8 ng/ml predicted chronic periodontitis with 81.3% sensitivity and 75.0% specificity（area under curve=0.834,95%CI=0.764~0.905,P0.001） respectively.Besides,plasma pentraxin 3 provides predicaltive value for chronic periodonitis.Conclusion Plasma pentraxin-3 level increases in patients with chronic periodontitis and pentraxin-3 maybe involved in pathophysiology of chronic periodontitis.
出处
《放射免疫学杂志》
CAS
2012年第6期681-682,共2页
Journal of Radioimmanology
关键词
穿透素-3
慢性牙周炎
病理生理
pentraxin-3
chronic periodontitis
pathophysiology
