摘要
目的观察血脂康对高血压患者血压及左心室重塑的影响。方法将60例高血压患者随机分为缬沙坦组(80mg/d,A组)和缬沙坦(80mg/d)联合血脂康组(1200mg/d,B组),各30例。连续药物治疗4个月,观察给药前后两组患者血压的变化,测定血清三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、及总胆固醇(TC)水平。心脏彩色超声仪测左室后壁厚度(LVPWT)和室间隔厚度(IVST),计算左室重量指数(LVMI)。结果药物治疗4个月后,B组较A组患者HDL-C显著增高,而TC、LDL-C及TG水平显著降低,差异均有统计学意义(P<0.05);两组患者收缩压和舒张压降低,B组血压显著低于A组(P<0.05);两组患者LVMI都明显降低,而B组患者LVMI显著低于A组(P<0.05)。结论血脂康可通过改善血管内皮功能、抑制左心室心肌细胞肥大及降低血压,达到影响高血压患者左心室重塑的作用。
Objective To observe the efficacy of Xuezhikang on hypertension in patients suffering from blood pressure and remouding of left heart. Methods 60 patients with hypertension were divided into two groups randomly： Therapy group （ n = 30） was given with valstrtan 80rag per day. Control group （ n = 30） was given with 80rag per day add Xuezhikang 1200rag per day. Keep 4 months, evaluate the change of blood pressure and the TG, HDL - C, LDL - C, TC and the LVPWT, IVST. Results Drug treatment after 4 months, in B group than in A group was signifieantly higher in patients with HDL - C, TC, LDL - C and TG levels were significantly deereased, the difference was statistically signifteant （ P 〈 0. 05 ） ; two groups of pa- tients with systolic and diastolic blood pressure decreased, B group was significantly lower than that in A group （ P 〈 0. 05） ; two patients LVMI decreased significantly, while B group of patients with LVMI was significantly lower than A group （ P 〈 0. 05 ）. Conclusion Xuezhi kang by improving endothelial function, inhibition of myocardial hypertrophy and decreased blood pressure, reach the effect in hypertensive patients with left ventrieular remodeling.
出处
《实用心脑肺血管病杂志》
2012年第12期1937-1938,1941,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
血脂康
高血压
血压
心室重构
Xuezhikang
Hypertension
Blood pressure
Ventricular remodeling
