摘要
目的通过探讨自身免疫性甲状腺疾病(AITD)患者血清促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPOAb)、抗甲状腺球蛋白抗体(TGAb)、促甲状腺激素受体抗体(TRAb)浓度的变化,探讨其在自身免疫性疾病的诊断价值。方法对30例毒性弥漫性甲状腺病(GD)、32例桥本甲状腺炎(HT)、24例甲状腺机能减退症患者和39例健康者采用化学发光法分别检测TSH、TPOAb、TGAb、TRAb,并观察这4种指标在不同疾病中的变化情况。结果甲状腺机能减退症组的TSH含量为(33.90±34.36)mIU/L,明显高于健康对照组,而GD组为(0.05±0.05)mIU/L,则明显低于健康对照组;GD组、HT组和甲状腺机能减退症组血清TPOAb、TGAb浓度明显高于健康对照组;GD组TRAb的含量为(11.34±12.07)IU/mL,显著高于其他3组,差异均有统计学意义(P<0.05)。结论 TSH是甲状腺功能的非常敏感的特异性指标,TPOAb、TGAb的检测对甲状腺疾病诊断有重要意义,而TRAb对于GD有较高的诊断价值,可以作为诊断GD病的特异性指标。
Objective To explore the value of measurement of thyroid stimulating hormone（TSH）, thyroid peroxidase antibodies（TPOAb）, thyroglohulin antibody （TGAb）, thyroid stimulating hormone receptor antibody （TRAb） in the autoimmune thyroid disease（AITD） ,and to explore its value in the diagnosis of autoimmune diseases. Methods the serum levels of TSH,TPOAB, TGAB and TRAB in 30 cases of Graves＇ disease（GD）,32 cases of Hashimoto thyroiditis（HT）,24 cases of hypothyroidism and 39 normal controls were measured by CLIA. Results the serum levels of TSH in patients with GD were significantly lower than that in the normal control, but the serum levels of tsh in patients with hypothyroidism were significantly higher than that in the normal control; the serum levels of TPOAb.TGAb in patients with GD,TH and hypothyroidism were significantly higher than that in the normal control;the serum levels of TRAb in patients with GD were significantly higher than that in TH,hypothyroidism and the normal control. Conclusion The serum TSH is very sensitive and special parameter of the function of the hypothyroidism. The comprehensive analysis of TPOAb, and TGAB might be helpful in the differential diagnosis of thyroid diseases. The serum TRAb GD disease had a higher diagnostic value as a specific marker for the diagnosis of GD disease.
出处
《检验医学与临床》
CAS
2012年第23期2968-2969,2971,共3页
Laboratory Medicine and Clinic
