摘要
目的:探讨C-FOS、MMP-9及Survivin在不同程度子宫内膜异位症患者表达变化及其价值。方法:选择2010年3月～2011年9月期间在该院妇产科经腹腔镜手术证实为子宫内膜异位症的60例患者,并将患者分为在位内膜组和异位内膜组,每组患者30例,同时选择同期入院行手术治疗的单纯子宫肌瘤患者30例为对照组。应用免疫组化法检测异位内膜组和在位内膜组以及正常内膜组中的C-FOS、MMP-9、Survivin表达情况,并对C-FOS、MMP-9及Survivin在不同程度子宫内膜异位症患者中表达变化的意义进行评价和分析。结果:与对照组相比,在位内膜组和异位内膜组患者的C-FOS、MMP-9以及Survivin蛋白的阳性率均明显提高,差异具有统计学意义(P<0.05)。同时,在位内膜组患者C-FOS、MMP-9以及Survivin蛋白的表达主要为阴性(-)至阳性(++),而异位内膜组患者C-FOS蛋白的表达主要为弱阳性(+)至强阳性(+++),MMP-9和Survivin蛋白的表达主要为阴性(-)至强阳性(+++)。结论:检测C-FOS、MMP-9及Survivin在不同程度子宫内膜异位症患者中的表达,对于探讨子宫内膜异位症的发生和发展以及协助临床诊断均具有极其重要意义,也为子宫内膜异位症全新疗法的探索开辟了更为广阔的思路。
Objective： To explore the expressions and values of C - FOS, MMP - 9, and Survivin in the patients with varying degrees of endometriosis. Methods ： A total of 60 patients diagnosed as endometriosis by laparoscopie surgery in the hospital from March 2010 to September 2011 were selected. Then the patients were divided into eutopic endometrium group and ectopic endometrium group, and 30 patients in each group. Thirty patients with uterine fibroids receiving surgical treatment in the hospital were selected as control group. Immuno- histochemical method was used to detect the expressions of C - FOS, MMP - 9, and Survivin in every group. The significances of expressions of C - FOS, MMP - 9, and Survivin in patients with varying degrees of endometriosis were evaluated and analyzed. Results： Compared with control group, the positive rate of C - FOS, MMP - 9, and Survivin protein in eutopic endometrium group and eetopic endometrium group significantly increased, there were significant differences （ P 〈 0. 05 ） . At the same time, the expressions of C - FOS, MMP - 9, and Survivin protein in eutopic endometrium group were mainly negative （ - ） to positive （ ＋ ＋ ） . But the expression of C - FOS protein in ectopic endometrium was mainly weakly positive （ ＋ ） to Xeon positive （ ＋ ＋ ＋ ）, and the expressions of MMP -9 and Survivin protein in ectopic endometfium group were mainly negative （ - ） to Xeon positive （ ＋ ＋ ＋ ） . Conclusion： Detecting the expression of C -FOS, MMP-9, and Survivin protein in patients with varying degrees of endometriosis has great significance for occurrence and development and clinical auxil- iary diagnosis of endometriosis. It also can explore new treatments to open up a broader way of thinking for endometriosis
出处
《中国妇幼保健》
CAS
北大核心
2012年第34期5596-5599,共4页
Maternal and Child Health Care of China
