摘要
目的:评价CTLA-4基因多态性与系统性红斑狼疮(SLE)易感性之间的相关性。方法:检索PubMed、Web of Knowledge、Embase、万方学术期刊全文数据库、中国期刊全文数据库和中国生物医学数据库,检索CTLA-4多态性与SLE易感性相关的文献,末次检索时间为2012-05-20。使用Meta分析方法对数据进行分析。结果:共纳入12篇文献,共涉及CTLA-4启动子区域3个多态位点:-1722、-166及-318位点,全人群研究结果显示在CTLA-4基因-1722T/C多态性(显性模型下:OR=2.570,95%CI=1.845-3.581,P<0.01)及-318T/C多态性(隐性模型:OR=0.044,95%CI=0.020-0.094,P<0.01)与SLE存在统计学上的相关性,人群分层后亚裔人群中-1722T/C及-318T/C多态性与SLE的此种相关性仍存在,但欧裔及非裔人群的CTLA-4启动区所有研究位点均未发现与SLE有关。结论:CTLA-4基因1722T/C及-318T/C多态性可能与SLE人群易感性有关,特别是亚裔人群。
AIM： To determine the correlation between CTLA-4 gene polymorphism and systemic lupus erythematosus （SLE） susceptibility. METHODS： We collected all the publications about the relationship between CTLA-4 gene polymorphism and SLE susceptibility by searching PubMed, Web of Knowledge, Embase, Wanfang, CNKI and CBM before the date of May 20, 2012. The data were analyzed by the method of meta-analysis. RESULTS： A total of 12 studies were included, involving 3 gene locus, - 1722, -1661 and -318. The results of total populations showed that there was a significant association between gene polymorphism and SLE risk in - 1722 gene locus under a dominant model （ OR = 2..5？0, 9,5% CI = 1. 845 - 3. 581, P 〈 0.01） and -318 gene locus under a recessive model （OR =0.044, 95%CI =0.020 -0.094, P〈0.01）. When stratified by population, the association still existed in Asian population, but no significant correlation existed in the other two populations （European and African）. CONCLUSION： This meta-analysis supports that the CTLA-4 1722T/C and -318T/C polymorphisms are associated with SLE susceptibility, especially in Asian population.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2012年第12期1320-1323,1327,共5页
Chinese Journal of Cellular and Molecular Immunology
