摘要
目的了解乙肝病毒表面抗原(HBsAg)阳性孕妇中乙肝病毒(HBV)感染相关指标分布特征,以评价HBV母婴阻断失败高危因素的分布强度及影响因素。方法采用现况调查方法,对2009年8月-2010年12月期间入选的895名HBsAg阳性孕妇进行人口学信息、与HBV感染相关的信息调查,采集血液样品检测HBsAg、HBeAg、抗-HBe及HBV DNA滴度等指标,并对结果进行统计分析。结果 HBsAg阳性孕妇产前HBeAg阳性率为33.4%,HBV DNA载量>107IU/ml者占25.2%,HBsAg滴度≥10 000IU/mL者占29.61%;HBeAg阳性者中,HBsAg滴度与HBV DNA载量间存在密切正相关关系(r=0.53,P<0.01);随孕妇年龄的增加,孕妇产前HBeAg阳性率和HBV DNA载量均有明显降低趋势。结论 HB-sAg阳性孕妇中存在母婴阻断失败高危险因素的比例较高。适当推迟怀孕年龄,可降低HBsAg阳性人群HBV母婴阻断失败的风险。
Objective To explore the distribution of HBV infection biomarkers in HBsAg positive pregnant women, and an alyze the causes of this distribution. Methods From Aug. 2009 to Nov. 2010, a structured questionnaire on demographic data was administered to eight hundred and ninety five HBsAg positive pregnant women, from whom blood samples were then col lected to test for HBsAg, HBeAg, Anti HBe and HBV DNA. The collected data were analyzed by SPSS software. ResultsOf the 895 subjects, 33.4% were HBeAgpositive, and 25.2% had HBV DNA levels of 107 IU/mL. Among HBeAg positive pregnant women, HBsAg titers were positively correlated with HBV DNA level （r= 0. 53,P〈0. 01）. There was a trend of decreased risk of mothertoinfant transmission with the increasing age. Conclusion In Chinese HBsAgpositive pregnant women, risk of HBV mothertoinfant transmission is relatively high, and delaying the age of pregnancy may low er the risk of HBV mothertoinfant transmission.
出处
《江苏预防医学》
CAS
2012年第6期17-19,共3页
Jiangsu Journal of Preventive Medicine
基金
传染病科技重大专项(2012ZX10002-001
2011ZX10004-902)
关键词
乙型肝炎病毒
孕妇
母婴阻断
危险因素
阳性率
HBsAg pregnant women block mother- to- infant transmission risk Sactor positive rate
