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SAPHO综合征16例临床分析 被引量:6

Clinical analysis of 16 cases with SAPHO syndrome
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摘要 对16例SAPHO综合征患者的临床资料进行分析和总结。显示患者以中青年多见,平均发病年龄(38±11)岁;16例中男7例,女9例,女性略多于男性。掌跖脓疱病和前胸壁骨关节、中轴关节、肩关节受累是最常见的临床表现,皮肤和骨关节病变可先后或同时发生。血清学检查和组织病理学检查为非特异性炎症,核素扫描可作为首选的影像学检查,治疗方案未统一,治疗方案以联合治疗为主。 The clinical data of 16 patients with synovitis, acne, pustulosis, hypemstosis, osteitis (SAPHO) syndrome were retrospectively analyzed. There were 7 men and 9 women with a mean age of (38 ± 11 ) years at onset and middle-aged females predominated. The most common clinical manifestationswere pahnoplantar pustulosis and osteoarticular disease inw)lving anterior chest wall, spondylarthrilides and shoulder joint. ECT was the sensitive imaging examination tor SAPHO syndrome. Combined treatment can alleviate synlptoms of the disease.
出处 《中华全科医师杂志》 2012年第12期936-939,共4页 Chinese Journal of General Practitioners
关键词 获得性骨肥大综合征 诊断 治疗 Acquired hyperostosis syndrome Diagnosis Therapy
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参考文献7

  • 1Hayem G, Bouchaud Chabot A, Benali K, et al. SAPHO syndrome: a long-term follow-up study of 120 cases. Semin Arthritis Rheum, 1999,29 : 159-171.
  • 2Hayem G. Valuable lessons from SAPHO syndrome. Joint Bone Spine ,2007,74 : 123-126.
  • 3Colina M, Govoni M, Orzincolo C, et al. Clinical and radiologic evolution of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a single center study of a cohort of 71 subjects. Arthritis Rheum,2009,61 : 813-821.
  • 4Grosjean C, Hurtado-Nedelec M, Nicaise-Roland P, et al. Prevalence of autoantibodies in SAPHO syndrome: a single-center study of 90 patients. J Rheumato1,2010,37:639-643.
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同被引文献80

  • 1李嗣钊,赵义,李小霞.唑来膦酸注射液治疗SAPHO综合征的疗效观察[J].中华临床医师杂志(电子版),2012,6(19):6069-6071. 被引量:3
  • 2张卓莉,和芳,邹海平,何俊梅.SAPHO综合征六例[J].中华医学杂志,2007,87(41):2952-2952. 被引量:10
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  • 6Colina M, Govoni M, Orzincolo C, et al. Clinical and radiologic evolution of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a single center study of a cohort of 71 subjects[J] . Arthritis Rbeum,2009,61 (6) :813-821.
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  • 9Eyrich GK, Langenegger T, Broder E, et al. Diffuse chronic sclerosing osteomyelitis and the synovitis, acne, pustulosis, hyperostosis, osteisis ( SAPHO) syndrome in two sisters[J]. IntJ Oral Maxillofac Surg,2000,29(1) :49-53.
  • 10Golla A,Jansson A, RamserJ, et al. Chronic recurrent multifocal osteomyelitis ( CRMO) : Evidence for a susceptibility gene located on chromosome ISq21. 3-18q22[J]. EurJ Hum Gener ,2002,10 (3) :217-221.

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