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维生素D干预治疗对糖耐量减低患者胰岛素抵抗的影响 被引量：3

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摘要 目的探讨糖耐量减低(IGT)患者维生素D(VitD)干预治疗后胰岛素抵抗的变化。方法 60例IGT患者随机分为治疗组和对照组30例,治疗组给予VitD3250 IU/d及钙剂600 mg/d,对照组不接受任何治疗。治疗3个月后观察两组空腹血糖(FPG)、空腹胰岛素(FINS)、血脂及胰岛素抵抗指数(HOMA-IR)等指标的变化。结果治疗3个月后,治疗组FPG、FINS及HOMA-IR较对照组均显著降低(P<0.05或<0.01)。线性回归分析显示血清VitD水平与IGT患者FPG、TG、HOMA-IR呈负相关(P均<0.05),与血清HDL-C呈正相关(P<0.05)。结论 IGT患者血清VitD水平与胰岛素抵抗密切相关,VitD3联合钙剂治疗对IGT患者胰岛素抵抗有改善作用。
作者 刘彦娥
机构地区 单县中心医院
出处 《山东医药》 CAS 2012年第41期75-77,共3页 Shandong Medical Journal
关键词 糖耐量减低 维生素D 胰岛素抵抗
分类号 R589.1 [医药卫生—内分泌]
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参考文献10

  • 1Holick MF. Vitamin D deficiency [ J]. N Engl J Med, 2007,357(3):266-281.
  • 2Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency andrisk of cardiovascular disease[ J] . Circulation, 2008 ,117 (4) :503-511.
  • 3Yang W, Lu J, Weng J, Jia W, et al. Prevalence of diabetes amongmen and women in China [ J] . N Engl J Med,2010,362 ( 12 );1090-1101.
  • 4Ganji V, Zhang X,Shaikh N, et al. Serum 25-hydroxyvitamin Dconcentrations are associated with prevalence of metabolic syndromeand various cardiometabolic risk factors in US children and adoles-cents based on assay-adjusted serum 25 -hydroxyvitamin D data fromNHANES 2001-2006[J]. Am J Clin Nutr, 2011,94(1):225-233.
  • 5Gagnon C, Lu ZX, Magliano DJ, et al. Serum 25-hydroxyvitaminD,calcium intake, and risk of type 2 diabetes after 5 years : resultsfrom a national,population-based prospective study ( the Australiandiabetes, obesity and life style study) [ J]. Diabetes Care, 2011,34(5) :1133-1138.
  • 6Pittas AG, Dawson-Hughes B, Li T,et al. Vitamin D and calciumintake in relation to type 2 diabetes in women[ J]. Diabetes Care,2006,29(7) :1579-1584.
  • 7Kim S, Lim J, Kye S, et al. Association between vitamin D statusand metabolic syndrome risk among Korean population: based on theKorean National Health and Nutrition Examination Survey IV-2,2008[J]. Diabetes Res Clin Pract, 2012,96(2) :230-236.
  • 8Clark SA, Stumpf WE, Sar M. Effect of 1,25 dihydroxy vitamin D3on insulin secretion[ J]. Diabetes, 1981,30(5) :382-386.
  • 9Wu T, Willett WC, Giovannucci E. Plasma C-peptide is inverselyassociated with calcium intake in women and with plasma 25 .hydroxyvitamin D in men[J]. J Nutr, 2009,139(3) :547-554.
  • 10Major GC, Alarie F, Dor6 J, et al. Supplementation with calcium+ vitamin D enhances the beneficial effect of weight loss on plasmalipid and lipoprotein concentrations[ J]. Am J Clin Nutr, 2007,85(1):54-59.

同被引文献25

  • 1Azziz R, Carmina E, Dewailly D, et al. The androgen excess and P- COS society criteria for the polycystic ovary syndrome: the complete task force report[J]. Ferti Steril, 2009,91 (2) : 456.
  • 2Goodarzi MO, Korenman SG. The importance of insulin resistance in polycystic ovary syndrome [ J ]. Fertil Steril,2003,80 ( 2 ) :255.
  • 3Muscogiuri G, Sorice GP, Prioletta A, et al. 25 - Hydmxyvitamin D concentration correlates with insulin - sensitivity and BMI in obesity [J]. Obesity,2010,18(10) :1906.
  • 4Cantoma MT, Mahon BD. Mounting evidence for vitamin D as an envi- ronmental factor affecting autoimmune disease prevalence[J]. Exp Biol Med,2004, 229 (11) : 1136.
  • 5Wang TJ, Pencim M J, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease [ J ]. Circulation,2008,117 (4) :503.
  • 6Pittas AG, Lau J, Hu FB, et al. The role of vitamin D and calcium in type 2 diabetes. A systematic review and mctaanalysis[ J]. J Clin Endo- crinol Metab ,2007,92(6) : 2017.
  • 7Scragg R, Sowers M, Bell C. Serum 25 - hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examina- tion Survey [ J ]. Am J Hypertens, 2007,20 ( 7 ) :713.
  • 8Foss YJ. Vitamin D deficiency is the cause of common obesity[ J]. Med Hypotheses ,2009,72 ( 3 ) :314.
  • 9Firoouzabad, Rd, Aflatoonian A, Modarresi S, et al. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS [ J ]. Complementa Ther Clin Prac,2012,18 (2) :85.
  • 10Mikes J, Kleban J, Sackova V, et al. Necrosis predominates in the cell death of human colon adenocarcinoma HT - 29 cells treated under vari- able conditions of photodynamic therapy with hyperiein [ J ]. Photoehem Photobiol Sci ,2007,6 ( 3 ) :758.

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山东医药
2012年 第41期

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