摘要
【目的】比较地特胰岛素联合餐前速效胰岛素及胰岛素泵对2型糖尿病患者（T2DM）疗效。【方法】选取78名T2DM患者，随机分为地特胰岛素联合餐前速效胰岛素组（Ⅰ组）及胰岛素泵组（Ⅱ组），比较两组疗效、安全性、治疗费用及生活质量等指标。【结果】两组患者治疗后血糖水平均较治疗前有显著改善（P〈0．05），达到预期指标。Ⅱ组患者生活质量较治疗前及Ⅰ组显著提高（P〈0．05）；两组患者均未发生低血糖事件及过敏反应，Ⅱ组血糖达标时间及胰岛素用量较Ⅰ组显著降低（P〈0．05），但费用增加（P〈0．05）。【结论】两种治疗方式各具特色，临床上应该根据患者自身情况，灵活实际地选择用药方式，以达到最佳的治疗效果。
[Objective] To compare the efficacy of insulin detemir combined with pre-meal short-action in- sulin vs continuous insulin pump for the treatment of patients with type 2 diabetes mellitus（T2DM）. [Meth- ods] A total of 78 T2DM patients were selected and randomly divided into insulin detemir combined with pre- meal short-action insulin group（group I ） and continuous insulin pump group（group 11 ）. The efficacy, safe- ty, treatment cost and quality of life were compared between two groups. [Results] Compared with before treatment, blood glucose in two groups after treatment was improved significantly（ P 〈0.05）, and reached the expected level. Compared with before treatment and group Ⅰ, the quality of life in group Ⅱ was significant- ly improved（ P 〈0.05）. No hypoglycemia and allergic response occurred in patients of two groups. Compared with group Ⅰ , the time for glycemia up to the standard and insulin dosage in group Ⅱ significantly decreased （ P〈0.05）, but the cost increased（ P 〈0.05）. [Conclusion]Two treatment ways have their own characteris- tics. In clinical practice, the treatment way should be actively and actually chosen on the basis of the situation of the patients in order to obtain the best clinical efficacy.
出处
《医学临床研究》
CAS
2012年第11期2148-2150,2153,共4页
Journal of Clinical Research
