摘要
动脉粥样硬化(atherosclerosis,AS)性病变是目前世界上心血管疾病的发生率与死亡率高的首位原因,严重危害人们的生命健康安全。动脉粥样硬化主要累及大中动脉,是一种慢性复杂的累进型病理过称。高同型半胱氨酸血症(Hyperho-mocysteinemia,HHcy)是动脉粥样硬化形成的独立危险因子,它可以通过转硫基作用等转化成硫化氢,但是其致病机制尚未完全阐明。近年来,硫化氢(hydrogen sulfide,H2S)因其在心血管健康和内稳态调节平衡方面的诸多积极性作用而受到重要关注。新近研究发现H2S在动脉粥样硬化病变过程中发挥重要作用。AS的发生发展与同型半胱氨酸(homocysteine,Hcy)和H2S存在一定的内在联系,本文拟对此方面的研究和认识作一综述。
Atherosclerotic lesions are the primary cardiovascular disease causing the highest rates of mortality resulting in serious harm to people＇s health and safety of life. Atherosclerosis is a chronic, complex, and progressive pathological process in large and me- dium sized arteries. Hyperhomocysteinemia has been recognized as an independent risk factor for atherosclerosis, which is converted to hydrogen sulfide （H2S） through the transsulfuration pathway. Controversy still remains though about its pathogenesis. H2S has attrac- ted considerable attention in recent years for many of its positive effects on vascular health and homeostasis. New research found H2 S in the atherosclerotic lesions play an important role in the process as happened with Hey and H2 S, which have certain developmental inter- nal relations. This paper reviews the research and understanding of these hydrogen sulfide processes.
出处
《川北医学院学报》
CAS
2012年第6期547-551,共5页
Journal of North Sichuan Medical College
基金
四川省科技厅(05SG1862)
四川省教育厅(11ZA193)
