摘要
目的:比较针刺联合赛乐特、电针联合赛乐特与单纯赛乐特治疗焦虑性抑郁症患者的疗效差异。方法:将102例患者随机分为药物组、手针药物组、电针药物组,每组34例。药物组单纯口服赛乐特,每日1次;手针药物组予赛乐特联合常规针刺治疗,取穴以百会、印堂为主;电针药物组予赛乐特联合电针治疗,在手针药物组治疗方案的基础上,于百会和印堂两穴连接电针,针刺均隔日1次,6周为一疗程,治疗1个疗程。治疗前后采用临床总体印象表(CGI)和世界卫生组织生存质量测定简表(WHOQOL-BREF)评定各组患者的情况。结果:①CGI情况比较:3组患者治疗后病情严重程度(SI)与治疗前比较均显著减轻(均P<0.001),但组间差异无统计学意义(P>0.05);治疗后3组间疗效总评(GI)的差异有统计学意义(P<0.05),其中电针药物组GI最佳,手针药物组次之,药物组最差,总进步率分别为100.0%(29/29)、96.9%(31/32)、93.5%(29/31);3组间疗效指数(EI)差异无统计学意义(P>0.05),其中药物组、手针药物组、电针药物组不良事件的发生数分别是1例(轻度失眠)、1例(中度食欲减退)、2例(轻度失眠、口干)。②WHOQOL-BREF情况比较:与治疗前比较,电针药物组治疗后各项指标均显著增高(均P<0.01);手针药物组除生理领域指标,其他指标均有改善(P<0.01,P<0.05);药物组只有生理领域、社会领域的分值显著高于治疗前(P<0.01,P<0.05);治疗后3组间仅有心理领域得分的差异有统计学意义(P<0.05),其中电针药物组改善较明显,手针药物组次之,药物组较差。结论:针药联合和单纯口服赛乐特均能改善焦虑性抑郁症患者的总体疗效和生存质量,且针药联合治疗优于单纯口服赛乐特者,电针优于手针。
Objective To compare the differences in the efficacy on agitated depression among the alliance therapy of acupuncture and seroxat,the alliance therapy of electroacupuncture and seroxat and the simple application of seroxat.Methods One hundred and two cases were randomized into a medication group,a conventional acupuncture ＋ medication group and an electroacupuncture ＋ medication group,34 cases in each one.In the medication group,seroxat was prescribed for oral administration,once per day.In the conventional acupuncture ＋ medication group,seroxat was applied in combination with the conventional acupuncture therapy,in which,Baihui（GV 20） and Yintang（EX-HN 3） were taken as the main acupoints.In the electroacupuncture ＋ medication group,seroxat was applied in combination with electroacupuncture,in which,on the basic therapeutic program as the conventio-nal acupuncture ＋ medication group,the electric stimulation was attached to Baihui（GV 20） and Yintang（EX-HN 3）.Acupuncture was applied once every two days,the treatment of 6 weeks made one session and one session treatment was required in the research.Before and after treatment,the clinical global impression（CGI） and the World Health Organization Quality of Life-BREF（WHOQOL-BREF） were adopted for the assessment in each group.Results（1） CGI comparison： the severity of illness（SI） after treatment was all alleviated significantly for the patients in three groups as compared with that before treatment（all P0.001）,but the difference was not significant statistically among groups（P0.05）.The global improvement（GI） was different significantly among three groups（P0.05）,in which GI in the electroacupuncture ＋ medication group was the best,that in the conventional acupuncture ＋ medication group was taken second place.The total improvement rates were 100.0%（29/29）,96.9%（31/32） and 93.5%（29/31） separately.The difference in the efficacy index（EI） was not significant statistically among three groups（P0.05）.Concerning to the adverse events,there were 1 case（mild insomnia） in the medication group,1 case（moderate anorexia） in the conventional acupuncture ＋ medication group and 2 cases（mild insomnia and dry mouth） in the electroacupuncture ＋ medication group.（2） WHOQOL-BREF comparison： compared with those before treatment,all the indices in the electroacupuncture ＋ medication group were increased significantly after treatment（all P0.01）;except the indices in the physiological field,all the other indices were improved in the conventional acupuncture ＋ medication group after treatment（P0.01,P0.05）;the scores only in the physiological field and social field were higher significantly than those before treatment in the medication group（P0.01,P0.05）.After treatment,the statistically significant difference was displayed only in the psychological field among three groups（P0.05）,in which,the improvement in the electroacupuncture ＋ medication group was the best,that in the conventional acupuncture ＋ medication group was taken second place and that in the medication group was the worst.ConclusionEither the alliance therapy of acupuncture and medication or the simple oral administration of seroxat improves the overall efficacy and the quality of life in the patients with agitated depression.The efficacy of the alliance therapy of acupuncture and medication is superior to the simple oral administration of seroxat and the efficacy of electroacupuncture is superior to the conventional acupuncture therapy.
出处
《中国针灸》
CAS
CSCD
北大核心
2012年第12期1063-1069,共7页
Chinese Acupuncture & Moxibustion
基金
国家科技支撑计划课题项目:2006BAI12B05-2
广东省"211工程"三期重点学科建设项目
