摘要
目的了解药品不良反应(ADR)发生的特点,为临床合理用药提供依据。方法收集第三军医大学新桥医院2011年1～12月上报的1 178例ADR报告,从患者年龄、药品种类、所涉及的器官及系统、临床表现、中药制剂、发生严重ADR的药品等方面进行分析。结果 1 178例报告涉及17类药物,其中抗肿瘤药引发ADR的比例最高(18.3%),60岁以上患者ADR发生率最高(31.7%),ADR的临床表现以胃肠系统损害较多(26.3%),由中药注射剂引发的ADR有149例(12.6%),严重ADR 21例(1.8%)。结论 ADR与多种因素有关,应加强ADR监测及相关知识的宣传,提高临床合理用药水平。
Objective To understand the characteristic of adverse drug reactions（ADR） for providing the basis to rational use in clinic. Methods From Jan. 2008 to Dec. 2008,1 178 cases of ADR in a hospital were analyzed inrespect of the patients＇age,drug categories,organs and systems involved,clinical manifestations,Chinese medicine injection and drugs developing Serious adverse reactions. Results Of the 1 178 ADR cases, 18.3% were induced by antineoplastic,12.6 % were caused by Chinese medicine injection, 1.8% were serious ADR,31.7% occurred in patients Over 60 years old,digestive system reaction were the main manifestations of ADR,which involved 26.3% of the cases. Conclusion Several Factors can induce ADR. ADR monitoring and Propaganda should be strengthened to improve rational use of drugs in clinic.
出处
《重庆医学》
CAS
CSCD
北大核心
2012年第34期3634-3635,3658,共3页
Chongqing medicine
关键词
药品不良反应
报告
分析
adverse drug reactions ~ report ~ analysis
