摘要
目的:探讨神经节苷脂(GM1)对缺氧缺血性脑病(HIE)新生儿神经行为发育的影响。方法:68例HIE新生儿,随机分为GM1治疗组35例,常规治疗组33例。两组患儿分别于3月龄和6月龄时测定神经精神运动发育商(DQ)。结果:GM1治疗组HIE患儿3月龄和6月龄DQ值均高于常规治疗组(P<0.05);GM1治疗组6月龄发育障碍发生率低于常规治疗组(P<0.05)。结论:GM1可改善HIE新生儿的神经行为发育,降低HIE患儿发育障碍发生率。
Objective： To explore the effect of ganglioside on neurobehavioral development of neonates with hypoxic ischemic en- cephalopathy （HIE） . Methods： Sixty - eight neonates with HIE were randomly divided into ganglioside treatment group （35 neonates） and routine treatment group （33 neonates） . Developmental quotients of neurobehavioral movement in the neonates at 3 months and 6 months were measured in the two groups. Results： Developmental quotients at 3 months and 6 months in ganglioside treatment group were statistical- ly significantly higher than those in routine treatment group （ P 〈 0. 05 ） . The morbidity of developmental disorders at 6 months in ganglio- side treatment group was statistically significantly lower than that in routine treatment group （ P 〈 0. 05 ） . Conclusion ： Ganglioside can improve neurobehavioral development and reduce the morbidity of developmental disorders in neonates with HIE.
出处
《中国妇幼保健》
CAS
北大核心
2012年第35期5712-5714,共3页
Maternal and Child Health Care of China
基金
廊坊市科学技术研究与发展计划支撑项目〔2011013084〕
关键词
发育障碍
DQ值
缺氧缺血性脑病
新生儿
神经节苷脂
Developmental disorders
Developmental quotient
Hypoxic isehemic encephalopathy
Neonate
Ganglioside
