摘要
目的:探讨居住入侵法制备经前期综合征(PMS)肝气逆证大鼠模型适用性。方法:采用居住-入侵法造模,记录并分析大鼠行为变化,经前平颗粒与白香丹胶囊药物干预反证模型可靠性。结果:造模组大鼠混合攻击行为得分为37.22±9.80,得分显著高于正常组;用药组大鼠行为学混合攻击行为得分分别为16.75±7.77和15.17±4.24,行为学指标在用药后均得到明显纠正;旷场实验中的水平得分、垂直得分及总分,造模组与正常组和用药组均有显著性差异(P<0.01)。结论:该模型是理想的PMS肝气逆证大鼠模型,经前平颗粒与白香丹胶囊对PMS肝气逆证均有较好的治疗效果。
Objective ： To explore the applicability of rat model of premenstrual syndrome with liver-qi invasion. Methods ： The model was made by residengt intruder paradigm. The behaviour was recorded and analysed, making counterevidence by Jingqianshu granule and Baixiangdan capsule. Results ： The average score of model group was 37.22± 9.80, which was higher than that of the normal group obviously. The average scores of using drug group were 16.75 ± 7.77 and 15.17 ±4.24, all behavioral indexes were obvious to rectify after using drug. Crossing, rearing and total score of open field test in the model group, normal group and treatment group were significant different （P 〈 0.01 ）. Conclusion：The established model was an ideal animal model of the rat model of premenstrual syndrome with liver-qi invasion, Jingqianshu granule and Baixiangdan capsule have effect on the liver-qi invasion of PMS. field
出处
《辽宁中医杂志》
CAS
2012年第12期2492-2494,共3页
Liaoning Journal of Traditional Chinese Medicine
基金
国家重点基础研究发展计划(973计划)资助课题(2011CB505102)
国家自然科学基金重点项目(30930110)
关键词
经前期综合征肝气逆证
居住入侵
大鼠模型
攻击行为
旷场
premenstrual syndrome with liver-qi invasion
resident intruder paradigm
rat model
aggressive behavior
open
