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康复新液治疗手足口病疗效的系统评价 被引量:11

Clinical Efficacy of Kangfuxin Liquid in Treatment of Hand-foot-mouth Disease: a Systematic Review
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摘要 目的:系统评价康复新液治疗手足口病的临床疗效。方法:计算机检索Cochrane图书馆,PubMed,CNKI,VIP,万方数据库。按Cochrane系统评价的方法评价纳入的研究质量,并进行Meta分析。结果:共纳入14项研究,1 792例患者。Meta分析结果显示,康复新液组在退热时间、口腔疱疹或溃疡减轻时间、皮疹消退时间及临床总有效率等方面均优于对照组;未报道康复新液临床应用的严重不良反应。结论:从现有的临床证据来看,康复新液治疗手足口病有效,安全性较高,但由于纳入的研究质量有限,降低了该系统评价结论的可靠性,尚需要开展更多高质量、多中心、大样本的随机对照试验来进一步证实。 Objective: To evaluate clinical efficacy of Kangfuxin liquid in the treament of hand-footmouth disease. Method: Literatures were retrieved from Cochrane library, PubMed, CNKI, VIP, WanFang. and Meta-analysis was performed. Result: Fourteen RCTs and 1 792 patients were included. The meta-analysis showed that Kangfuxin liquid-treated group was better than control group in terms of defervescence time, oral herpes or ulcer improvement time, the skin rash regression time and the total clinical efficacy. Serious adverse drug reactions (ADRs) induced by Kangfuxin liquid hadn't been reported. Conclusion: Actual clinical evidence indicated that efficacy and safety of Kangfuxin liquid in the treament of Hand-Foot-Mouth Disease. The reliability of systematic review is affected by low quality of included study. More randomized controlled trial of high-quality large-scale multiple-centered should be carried out.
出处 《中国实验方剂学杂志》 CAS 北大核心 2012年第24期13-19,共7页 Chinese Journal of Experimental Traditional Medical Formulae
关键词 康复新液 手足口病 META分析 Kangfuxin liquid hand-foot-mouth disease Meta-analysis
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