期刊文献+

益生菌在儿童哮喘防治中的作用 被引量:5

The role of probiotics in the prevention and treatment of childhood asthma
原文传递
导出
摘要 “卫生学假说”可能是导致近年来儿童哮喘发病率增加的原因,大量的临床试验表明在消化系统疾病方面起着积极作用的益生菌制剂能够预防和治疗儿童特应性皮炎、食物过敏,但对预防、治疗哮喘的结论不一,越来越多的动物实验显示了益生菌在哮喘的预防或治疗方面的积极作用,其机制仍在探索中,以乳酸杆菌为代表的益生菌制剂在未来可能为儿童哮喘的临床防治提供新的思路。 "Hygiene hypothesis" may be the reason for the increased incidence of childhood asthma in recent years. A large number of clinical studies indicate that, probiotics, which play a positive role in the digestive system diseases, can prevent and treat children atopic dermatitis as well as food allergies, but the conclusions of prevention and treatment of asthma have been inconsistent. More and more of the animal experiments show that probiotics have benefical effects in the prevention or therapy of asthma,its mechanism is still in the exploration, probiotics such as lactobacillus will provide a new clinical thought for the prevention and treatment of childhood asthma in the future.
出处 《国际儿科学杂志》 2012年第6期545-548,553,共5页 International Journal of Pediatrics
关键词 哮喘 益生菌 预防 治疗 Asthma Probiotics Prevention Treatment
  • 相关文献

参考文献3

二级参考文献28

共引文献49

同被引文献63

  • 1王长文,张岚,马洪波.双歧杆菌对肠黏膜粘附及免疫调节功能的研究进展[J].吉林医药学院学报,2010,31(1):42-45. 被引量:18
  • 2蔺兴娟,魏春华,王寒,杜秀伟,张翠翠,刘艳红,李国华,管华东,温明春.支气管扩张症合并支气管哮喘患者支气管肺泡灌洗液病原菌培养及药敏状况研究[J].中华哮喘杂志(电子版),2013,7(3):20-24. 被引量:11
  • 3武其文,陈其御.几种人源乳酸杆菌的免疫调节及抑瘤作用[J].基础医学与临床,2007,27(2):183-186. 被引量:10
  • 4Kau AL, Korenblat PE. Anti-interleukin 4 and 13 for asthmatreatment in the era of endotypes[J]. Curr Opin Allergy ClinImmunol,2014,8(25) : 122-123.
  • 5Li J, Lin LH, Wang J,et al. Interleukin-4 and interleukin-13pathway genetics affect disease susceptibility,serum immuno-globulin E levels,and gene expression in asthma[J]. Ann Aller-gy Asthma Immunol.2014. 113(2) : 173-179.
  • 6Liu Y, Zhuo A, Liu W, et al. The -33C/T polymorphism in theinterleukin 4 gene is associated with asthma risk: a meta-analy-sis[J]. J Investig Allergol Clin Immunol, 2014,24(2) :114-121.
  • 7Al-Muhsen S. Vazquez-Tello A, Alzaabi A, et al. IL-4 receptoralpha single-nucleotide polymorphisms rsl805010 and rsl801275are associated with increased risk of asthma in a Saudi Arabianpopulation[j]. Ann Thorac Med,2014,9(2) :81-86.
  • 8Khaitov MR, Shilovskiy IP,Nikonova AA,et al. Small interfer-ing RNAs targeted to interleukin-4 and respiratory syncytial vi-rus reduce airway inflammation in a mouse model of virus-in-duced asthma exacerbationCJl. Hum Gene Ther, 2014, 25(7):642-650.
  • 9Tang L,Lin HG’Chen BF,et al. Association of IL-4 promoterpolymorphisms with asthma: a meta-analysis [J]. Genet MolRes,2014,13(1):1383-1394.
  • 10Yap GC,Chee KK,Hong PY,et al.Evaluation of stool microbiota signatures in two cohorts of Asian(Singapore and Indonesia)newbo- rns at risk of atopy[J].See comment in PubMed Commons belowB- MC Microbiol,2011,11:193.

引证文献5

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部