摘要
辐射敏感性是肿瘤细胞复杂的生物学现象 ,在辐射诱导的细胞反应中具有不同的组织细胞类型特异性。肿瘤辐射敏感性与辐射诱导的细胞凋亡密切相关 ,并受 p5 3及其相关蛋白、Bcl- 2基因家族蛋白、Fas及神经鞘磷脂 -神经酰胺介导的信号途径、caspases级联反应等调控。
Radiosensitivity is a complex phenomenon in tumor cells and there exist special biological effects in different types of tissues' cells in inadiation induced cell responses. Tumor radiosentivity is tightly connected with irradiation induced apoptosis and is regulated by many protein products of apoptosis related genes such as p53 and related proteins, Bcl 2 gene family proteins, Fas and sphingomyelin/ceramide mediated signalling pathways and caspases cascade etc.
出处
《国外医学（放射医学核医学分册）》
2000年第2期78-82,共5页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
关键词
辐射敏感性
细胞凋亡
信号途径
肿瘤
radiosensitivity
apoptosis
signaling pathway
regulation of gene expression
