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子宫内膜样腺癌中KLK7、E-Cad的表达及其与病情的相关性 被引量：2

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摘要 目的探讨人角化层糜蛋白酶(KLK7)和E-钙黏蛋白(E-Cad)在子宫内膜样腺癌组织中的表达及其与病情的相关性。方法采用Western印迹检测10例增生期子宫内膜、10例不典型增生子宫内膜、30例子宫内膜样腺癌标本中KLK7、E-Cad蛋白的表达,分析其与各临床病理指标的相关性。结果 (1)KLK7、E-Cad在子宫内膜样腺癌中的蛋白表达与年龄无关;随着临床分期增高、组织分化降低、深肌层浸润、患者手术时有淋巴结转移,KLK7蛋白的阳性表达率呈上升趋势(P<0.01),而E-Cad的阳性表达率呈下降趋势(P<0.01,P<0.05)。(2)在子宫内膜样腺癌中KLK7蛋白和E-Cad表达呈负相关(P<0.05)。结论 KLK7蛋白在子宫内膜样腺癌中呈高表达,E-Cad在子宫内膜样腺癌中表达下降,两者可能与子宫内膜癌的病情进展及侵袭转移相关;KLK7蛋白和E-Cad在子宫内膜样腺癌组织中表达呈负相关,在子宫内膜癌侵袭转移中可能有协同效应。
作者 白兰 王迪迪 王春敏 姚海涛 卢北燕 朱贵明 佟秀凤 张燕 佟丽波
机构地区 佳木斯大学附属第一医院 佳木斯大学基础医学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第23期5107-5108,共2页 Chinese Journal of Gerontology
基金 黑龙江省教育厅科学技术研究资助项目(No.12511538) 黑龙江省2011年研究生创新科研资金项目(No.YJSCX2011-381HLJ)
关键词 子宫内膜样腺癌 KLK7 E—Cad
分类号 R737 [医药卫生—肿瘤]
  • 相关文献

参考文献6

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二级参考文献10

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共引文献1

同被引文献33

  • 1刘登洋,陈百芳,曹华祥,孟东,狄长华.环氧合酶-2和p27^(kip1)蛋白在幽门螺旋杆菌感染胃癌变过程中的表达及其机制[J].中华实验外科杂志,2005,22(10):1193-1194. 被引量：3
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  • 5Zhu FS,Chen XM,Huang ZG. Rofecoxib augments anticancereffects by reversing intrinsic multidrug resistance gene expression inBGC-823 gastric cancer cells[J].J Dig Dis,2010,(1):34.
  • 6Georgopoulos NT,Kirkwood LA,Walker DC. Differentialregulation of growth-promoting signalling pathways by E-cadherin[J].PLoSOne,2010,(10):e13621.
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  • 8Lau MT,Klausen C,Leung PC. E-cadherin inhibits tumor cell growth by suppressing PI3K/Akt signaling via b-catenin-Egr1-mediated PTEN expression[J].{H}ONCOGENE,2011,(24):2753-2766.
  • 9Yeh TS,Wu CW,Hsu KW. The activated Notch1 Signal Pathway is associated with gastric cancer progression through Cyclooxygenase-2[J].{H}CANCER RESEARCH,2009,(12):5039-5048.
  • 10De Santis G,Miotti S,Mazzi M. E-cadherin directly contributes to PI3K/AKT activation by engaging the PI3Kp85 regulatory subunit to adherens junctions of ovarian carcinoma cells[J].{H}ONCOGENE,2009,(9):1206-1217.

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中国老年学杂志
2012年 第23期

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