摘要
目的观察芪药消渴胶囊对2型糖尿病前期患者临床疗效。方法糖尿病前期患者116例,按2∶1比例分为中药组、对照组,其中中药组76例,对照组40例,两组患者均给予适当控制饮食、健康教育、运动等一般治疗。中药组在此基础上口服芪药消渴胶囊(0.4g/粒)每次6粒,每日3次,对照组以单纯生活方式干预,观察两组患者干预前后空腹血糖(FBG)及餐后2h血糖(PBG)、胰岛素(FINS、2hINS)、糖化血红蛋白(HbA1c)、血脂(TG、TC、HDL-C、LDL-C)及中医证候疗效,并观察疗程结束及随访转归情况。结果两组患者FBG、PBG、HbA1c治疗后均较治疗前下降(P<0.05,P<0.01),尤以2hPBG下降显著,但两组间比较,差异无统计学意义(P﹥0.05);两种方法皆能改善FINS分泌,尤以中药组2hINS较治疗前下降明显,与对照组比较,差异有统计学意义(P<0.05);两种方法皆能改善患者血脂代谢,中药组TG显著降低,HDL-C升高,与治疗前比较,差异有统计学意义(P<0.05);中药组中医证候较治疗前明显改善,与对照组比较,差异有统计学意义(P<0.05);疗程结束及随访中药组复常率优于对照组(P<0.05)。结论中药芪药消渴胶囊结合生活方式干预,能改善糖尿病前期患者空腹及餐后胰岛素分泌、调节糖脂代谢,纠正胰岛素抵抗状态,改善气阴两虚症状,有一定延缓或阻止2型糖尿病的发生发展作用,较单纯生活方式持久有效。
Objective To observe the clinical effects of Qiyao Xiaoke Capsule （QXC） on patients with type 2 pre-diabetes. Methods Totally 116 pre-diabetes patients were randomly assigned to the Chinese medicine group （CM, 76 cases） and the blank control group （ BC, 40 cases） in the ratio of 2： 1. All patients received proper diet control, health education, and exercises, and so on. Besides, patients in the CM group took QXC （0.4 g/pill）, 6 pills each time, three times a day. But patients in the BC group were intervened by life style a- lone. The fasting blood glucose （ FBG）, postprandial blood glucose （ PBG）, insulin （ FINS, 2h INS）, glycosylat- ed hemoglobin （HbAlc）, blood lipids （TG, TC, HDL-C, and LDL-C）, and efficacy of CM symptoms were ob- served in the two groups before and after intervention. The sequelae were observed at the end of the treatment and at follow-ups. Results After treatment FBG, PBG, and HbAlc decreased in all patients of the two groups （P〈0.05, P〈 0.01 ）, with 2 h PBG decreased more significantly. But there was no statistical difference be- tween the two groups （ P〉0. 05）. The two methods could improve the secretion of FINS. Especially 2 h INS de- creased more significantly in the CM group, showing statistical difference when compared with the BC group （ P 〈 0.05）. The two methods could improve the metabolism of blood lipids. CM could significantly lower TG and ele- vate HDL-C, showing statistical difference when compared with before treatment （P 〈0.05）. After treatment the CM symptoms were obviously improved, showing statistical difference when compared with the BC group （ P 〈 0.05）. The normalization rate was better in the CM group than in the BC group at the end of the treatment and at follow-ups （ P 〈0. 05）. Conclusions QXC combined life style intervention could improve fasting and postprandial insulin secretion of type 2 pre-diabetes patients, regulate glycolipid metabolism, correct the insulin resistance state, and improve the symptoms of qi-yin insufficiency. It could postpone or hinder the occurrence and development of type 2 diabetes. It was more effective and durable than changing the life style alone.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2012年第12期1628-1631,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
陕西省"13115"科技创新工程重大科技产业化计划项目(No.2008ZDCY-25)
陕西省教育厅课题(No.09JK412)
咸阳市科技计划项目[No.XK0914-2(3)
2011K13-05(2)]
