摘要
目的:探讨与乳腺癌保乳术后局部复发相关的因素。方法:回顾性分析2000年1月—2007年12月接受保乳手术的548例乳腺癌患者的病历资料并进行随访。对与乳腺癌保乳术后局部复发相关的因素进行单因素和多因素分析。结果:548例患者中,局部复发22例(4.01%)。年龄(<45岁和≥45岁,P=0.041)、肿瘤大小(T1、T2和T3,P=0.014)和组织学分级(Ⅰ～Ⅱ级和Ⅲ级,P=0.003)与局部复发相关。多因素分析结果显示,年龄(<45岁和≥45岁,P=0.013)和组织学分级(Ⅰ～Ⅱ级和Ⅲ级,P=0.046)是影响乳腺癌保乳术后局部复发的独立因素。结论:青年乳腺癌患者(<45岁)保乳术后具有相对较高的局部复发风险,临床医师应当采取更为积极的治疗措施以预防局部复发。
Objective： This study was designed to evaluate the effect of age on local recurrence after BCT （breast-conserving therapy） in patients with breast cancer. Methods： The clinical records of 548 female patients with breast cancer undergoing BCT between January 2000 and December 2007 were analyzed retrospectively, and the follow-up of these patients was performed. The univariable and multivariabe analyses were conducted to evaluate the potiential factors related to local recuurence after BCT. Results： For 548 patients, the recurrence rate within 5 years after BCT accounted for 4.01% （22/548）. There were statistical differences in local recurrence rate among different ages （ 45 years vs ≥ 45 years, P = 0.041）, tumor sizes （T1 vs T2 vs T3, P = 0.014） and histologic grades （grades Ⅰ-Ⅱ vs grade Ⅲ, P = 0.003）. The multivariable analysis displayed that the factors of younger age （ 45 years, P = 0.013） and higher histologic grade （grade Ⅲ, P = 0.046） were independent factors in prediction of poor prognosis of breast cancer after BCT. Conclusion： Younger age （ 45 years） is a reasonable justification to consider more aggressive treatment to prevent local recurrence in patients with breast cancer after BCT.
出处
《肿瘤》
CAS
CSCD
北大核心
2012年第12期1009-1014,共6页
Tumor
关键词
乳腺肿瘤
保乳手术
局部复发
年龄
Breast neoplasms
Breast-conserving therapy
Local recurrence
Age
