摘要
目的研究美托洛尔治疗原发性高血压的疗效及其对血管内皮功能的影响。方法 60例原发性高血压患者,分为观察组和对照组。对照组给予氨氯地平治疗;观察组采用氨氯地平联合美托洛尔治疗。结果治疗后,两组患者血压和心率均明显改善;但观察组改善更明显,组间比较差异有统计学意义(P<0.05或0.01)。治疗后,两组ET-1、NO、FMD均明显改善。结论美托洛尔可以有效的降低血压,改善血管内皮功能。
Objective To study of metoprolol in the treatment of essential hypertension and the intervention of vascular endothelial function. Methods 60 patients with primary hypertension patients were divided into the control group and the observation group. The control group was treated with amlodipine, and the observation group was treated with amlodipine and metoprolol. Results After treatment, blood pressure and heart rate of patients in both group were significantly improved. Blood pressure and heart rate of the observation group were better than the control group,which had significant difference （P 0.05 or 0.01）. After treatment, two groups of ET-1, NO, FMD were significantly improved. Conclusion Metoprolol can reduce blood pressure and improve endothelial function.
出处
《中国医药科学》
2012年第18期43-44,共2页
China Medicine And Pharmacy
关键词
美托洛尔
原发性高血压
血管内皮功能
氨氯地平
Metoprolol
Primary hypertension
Vascular endothelial function
Amlodipine
