摘要
目的探讨清热解毒法治疗肝胆湿热型肝硬化的临床疗效。方法将86例黄疸型肝硬化患者分成治疗组和对照组,对照组给予拉米夫定治疗,治疗组给予拉米夫定联合清热解毒法治疗,观察两组临床疗效、ALT复常率、YMDD变异率、HBeAg和HBVDNA低于监测下限的比率。结果治疗组的总有效率为97.67%,明显高于对照组的88.37%(P<0.05);治疗结束12个月后,治疗组的ALT复常率、HBeAg转阴率和低于检测下限的比率、HBVDNA低于监测下限的比率均高于对照组,YMDD变异率低于对照组,组间比较差异有统计学意义(P<0.05)。结论清热解毒法可明显改善肝功能,促进HBeAg转阴,降低YMDD变异率,提高总有效率,联合拉米夫定疗效显著,值得临床推广使用。
Objective To investigate the clinical efficacy of the heat-clearing and detoxicating remedy on the treatment of hepatic cirrhosis with liver-gallbladder dampness-heat syndrome. Methods 86 patients of icteric hepatic cirrhosis were divided into the treatment group and the control group. The control group was treated with lamivudine,while the treatment group was treated with heat-clearing and detoxicating remedy additionally. Clinical efficacy,ALT recovery rate,YMDD mutation rate,and rates of HBeAg and HBVDNA below the monitoring floor are observed. Results The ORR of the treatment group is 97.67%,significantly higher than 88.37% of the control group （P 0.05）. As for the treatment group,12 months after treatment,its ALT recovery rate,and HBeAg negative converting rate and HBVDNA rate below the monitoring floor were all lower than those of the control group,while the YMDD mutation rate was higher than that of the control group （P 0.05）. Conclusion The heat-clearing and detoxicating remedy can significantly improve liver functions,enhance the negative transformation of HBeAg,reduce the YMDD mutation rate and increase the ORR. Therefore,combined with lamivudine,the remedy is worthy of clinical application.
出处
《中国医药科学》
2012年第21期66-67,共2页
China Medicine And Pharmacy
关键词
乙型肝炎
肝硬化
清热解毒法
Hepatitis B
Hepatic cirrhosis
Heat-clearing and detoxicating remedy
