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3-磷酸甘油醛脱氢酶测定在糖尿病肾病诊断中的临床意义 被引量:1

Diagnositic value of glyceraldehyde-3-phosphate dehydrogenase determination in diabetes nephropathy
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摘要 目的通过测定血中3-磷酸甘油醛脱氢酶的活性,探讨GAPD在糖尿病肾病早期诊断中的意义。方法测定190例健康者和80例2型糖尿病患者的血GAPD,尿微量白蛋白和β2-微球蛋白,对结果进行统计分析。结果疾病组中GAPD活性水平均高于正常对照组,差异有统计学意义(P<0.05)。疾病组中的微量白蛋白尿组、大量白蛋白尿组中的微量白蛋白和β2-微球蛋白高于正常对照组,差异有统计学意义(P<0.05)。但是正常白蛋白尿组中的微量白蛋白和β2-微球蛋白与对照组相比差异无统计学意(P>0.05)。结论 GAPD在正常白蛋白尿期活性已经发生变化,比微量白蛋白和β2-微球蛋白活性变化更早,能够提早预测糖尿病肾脏疾病的发生,有利于临床做出诊断,改善患者的预后。 Objective To explore the significance of GAPD in diabetic nephropathy through determining the activity of blood GAPD.Methods To analyze the determined results of 190 healthy and 80 patients of type 2 diabetes patients,the activity of GAPD,microalbuminuria and β2-micro-globulin.Results Activity of GAPD in three disease group were higher than the normal group(P0.05).mALB and β2-M in two disease group of the abnormal microalbuminuria group were higher than the control group(P0.05),but compared with the control group mALB and β2-M in normal albuminuria group had no significant difference(P0.05).GAPD in disease group had no difference(P0.05).mALB and β2-M meaningful were differences between the three groups(P0.05).Conclusion Activity of GAPD has been changed in normal proteinuria and earlier than mALB and β2-M.It can be forecast early diabetic kidney disease,easy to make a diagnosis for clinic and improve the prognosis of patients.
出处 《中国医药科学》 2012年第22期116-117,130,共3页 China Medicine And Pharmacy
关键词 3-磷酸甘油醛脱氢酶 2型糖尿病 微量白蛋白 Β2-微球蛋白 Glyceraldehyde-3-phosphate dehydrogenase Type 2 diabetic Albumin β2-micro-globulin
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  • 1叶山东.尿蛋白系列检测对糖尿病性肾病的早期诊断意义[J].国外医学(内科学分册),1994,21(7):289-291. 被引量:11
  • 2郑富盛.细胞形态立体测量学[M].北京:北京医科大学中国协和医科大学联合出版社,1990.36.
  • 3Makino H, Shikata K, Hironaka K, et al. Ultrastructure of nonenzymatically glycated mesangial matrix in diabetic nephropathy. Kidney Int, 1995,(48):517
  • 4Sharon GA, Stella F, Liliane S, et al.Glomerular type Ⅳ collagen in patients with diabetic nephropathy with and without additional glomerular disease. Kidney Int,2000, 57:2084
  • 5Pascale H, Lane MW, Steffes PF, et al. Renal interstitial expansion in insulin-dependent diabetes mellitus. Kidney Int,1993, 43(3):661
  • 6Bjorn SF, Bangstad HJ, Hanssen KF, et al. Glomerular epithelial foot processes and filtration slits in IDDM patients. Diabetologia,1995, 38(10):1197
  • 7Report of a WHO consulation:Definition,diagnosis and classiffication of Diabetes Mellitus and its complication,WHO/NCD/NCS/1999,31-33.
  • 8Thornley C,Dawnay A,Cattell WR.Human Tamm-Horsfall glycoprotein:urinary and plasma levels in normal subjects and patients with renal disease determined by a fully validated radioimmunoassay[J].Clin Sci (Lond),1985,68(5):529-535.
  • 9杜同信,王自正,周鹏,李纲,陈崇华.糖尿病肾病患者24小时尿Alb、β_2-MG、THP、C-肽RIA测定的临床应用[J].标记免疫分析与临床,1998,5(3):128-130. 被引量:2
  • 10刘志红,黎磊石.糖尿病肾病发病机理[J].中华肾脏病杂志,1999,15(2):120-123. 被引量:314

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