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Notch信号通路与心脏发育、先天性心脏病及心肌再生 被引量：7

Notch signaling pathway and its role in cardiac development,congenital heart disease and myocardial regeneration
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摘要 Notch信号通路在细胞决定、发育、分化、增殖、凋亡、粘附及上皮-间质细胞转化过程中发挥重要作用,并参与了心脏发育的关键过程,也与心肌再生修复密切相关,Notch位点突变可引起一系列心脏畸形。本综述将集中讨论Notch信号通路及其在心脏发育、先天性心脏病和心肌再生中的作用。 Notch signaling is essential for cell fate decisions, cellular development, differentiation, prolifera- tion, apoptosis, adhesion and epithelial-to-mesenchymal transition. Notch signaling plays a critical role during mammalian cardiogenesis, and is closely related to myocardial regeneration and repair. The mutations in the Notch signaling has been associated with human congenital heart diseases. Therefore, this review focuses on the progress of Notch signaling and its role in cardiac development, congenital heart disease and myocardial regeneration.
作者 周学亮 刘季春
机构地区 南昌大学第一附属医院心脏外科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2012年第12期887-889,共3页 Journal of Clinical Cardiology
基金 国家自然科学基金资助项目(No:81260024) 江西省研究生创新专项资金(No:YC2011-B013)
关键词 先天性心脏病 NOTCH信号通路 心脏发育 congenital heart disease Notch signaling pathway cardiogenesis
分类号 R541.1 [医药卫生—心血管疾病]
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  • 1SCHWANBECK R, MARTINI S, BERNOTH K, et al. The Notch signaling pathway: molecular basis of cell context dependency[J]. Eur J Cell Bioh 2011,90 : 572-581.
  • 2MIAZGA C M, McLAUGHLIN K A. Coordinating the timing of cardiac precursor development during gastrulation: a new role for Notch signaling[J]. Dev Biol, 2009,3'33 " 285 - 296.
  • 3DE LA POMPA J L, EPSTEIN J A. Coordinating tissue interactions: Notch signaling in cardiac develop- ment and disease[J]. Dev Cell, 2012,22 : 244 - 254.
  • 4KOKUBO H, TOMITA-MIYAGAWA S, HAMA- DA Y, et al. Hesrl and Hesr2 regulate atrioventrjcu- lar boundary formation in the developing heart through the repression of Tbx2 [J]. Development, 2007,134:747-55.
  • 5TIMMERMAN I. A, GREGO-BESSA J, RAYA A, et al. Notch promotes epithelial-mesenchymal transi- tion during cardiac development and oncogenic trans- formation[J]. Genes Dev, 2004,18 " 99 - 115.
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临床心血管病杂志
2012年 第12期

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