摘要
目的:比较不同类型、不同病变支数冠心病患者的血清脂肪细胞型脂肪酸结合蛋白(A-FABP)的血清水平,分析其与冠心病的关系。方法:选择冠心病患者64例,同期造影阴性对照组24例。采用固相夹心酶偶联免疫吸附法(ELISA)检测A-FABP、白细胞介素6(IL-6)含量,免疫散射比浊法测定血清高敏C反应蛋白(hs-CRP)。结果:A-FABP水平在对照组[5.96(4.87～7.99)ng/ml]较冠心病组[7.76(6.28～9.12)ng/ml]明显降低(P<0.05)。A-FABP水平在多支病变组[9.33(8.04～11.09)ng/ml]较单支病变组[6.61(5.62～7.59)ng/ml](P<0.01)高。A-FABP与IL-6呈正相关(r=0.592,P<0.01),与hs-CRP呈正相关(r=0.604,P<0.01)。Logistic回归分析示血清A-FABP水平与冠心病危险度呈正相关(χ2=21.734,P<0.01)。结论:血清A-FABP水平与冠心病的病变程度、IL-6、hs-CRP及冠心病危险度呈正相关。
Objective：To detect the serum adipocyte fatty acid binding protein （A FABP） in patients with cor- ollary heart disease （CHD）. Methods： 64 patients with CHD and 24 controls with normal coronary arteris were enrolled. Serum A-FABP and interleukin-6 （IL 6） were detected by ELISA, while serum hs-CRP was detected by immunoturbidimetry. Results=Serum A-FABP was significantly higher in patients with CHD E7.76 （6.28--9.12） ng/ml] than that in control group [5.96（4.87-7.99）ng/ml] （P〈0.05）. Serum A-FABP in multi-vessel lesions group [9.33（8. 04-11.09）ng/rnl] was significantly higher than that in single-vessel lesion group [6.61（5.62-7.59）ng/ml] （P〈0.01）. Serum A-FABP positively correlated with serum IL-6 （r=0. 592, P〈0.01） and hs-CRP （r=0. 604, P〈0.01）. Logistic regression analysis showed that serum A-FABP level and CHD were closely related （x2 = 21. 734, P〈0.01）. Conclusion.. Serum levels of A-FABP is positively correlated with the coronary lesions, 1176, hs-CRP, which may be a risk factor of CHD.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
2012年第12期922-924,共3页
Journal of Clinical Cardiology
关键词
冠心病
脂肪细胞型脂肪酸结合蛋白
白细胞介素-6
高敏C反应蛋白
coronary heart diseasel adipocyte fatty acid-binding protein
interleukin-61 high sensitivity C- reactive protein
