摘要
目的比较来自艾滋病防治机构(简称"艾防机构")和结核病防治机构(简称"结防机构")的HIV阳性结核病患者的特征及抗结核治疗效果。方法从结核病信息管理系统中导出6省14个县2年时间结核病患者患病和治疗的相关信息,从艾滋病防治机构收集HIV阳性患者的相关信息。从2007年9月1日至2009年8月31日期间共登记报告HIV检测阳性的肺结核患者925例。673例(72.8%)为艾防机构转诊的已知HIV阳性患者,252例(27.2%)为结防机构新检出HIV阳性患者。结果在HIV主要由采供血传播的地区,艾防机构转诊的HIV阳性结核病患者和结防机构新发现的HIV阳性结核病患者治疗成功率分别为90.6%(328/362)和82.4%(70/85)(χ2=4.806,P=0.034),病死率分别为7.5%(27/362)和16.5%(14/85)(χ2=6.711,P=0.010)。在HIV主要通过吸毒和性传播的地区,艾防机构和结防机构发现的患者治疗成功率分别为60.1%(187/311)和68.9%(115/167)(χ2=3.563,P=0.059),不良反应率分别为24.1%(75/311)和13.8%(23/167)(χ2=7.132,P=0.009)。结论应继续加强在HIV感染者与AIDS患者中筛查结核病的工作,同时在结核病患者中筛查HIV感染也是一项很重要的挽救措施。
Objective To compare the characteristices and anti-TB treatment outcome of HIV-positive TB patients from TB programme and AIDS programme.Methods We collected the TB-related information from TB information management system and HIV-related information from HIV institutions.In the selected fouteen counties within six provinces,a total of 925 TB/HIV cases were registered between Spe.2007 and Aug.2009,673（72.8%） were known to be HIV positive and referred by HIV institutions and 252（27.2%） were newly detected HIV positive cased by TB institutions.Results In areas where HIV transmited mainly through illegal blood donation,the treatment success rate was 90.6%（328/362）and 82.4%（70/85）（χ2=4.806,P=0.034）and the death rate was 7.5%（27/362）and 16.5%（14/85）（χ2=6.711,P=0.010）repsectively for TB/HIV patients from HIV institutions and TB institutions.In areas where HIV transmited mainly through drug use and sex,the treatment success rate was 60.1%（187/311）and 68.9%（115/167）（χ2=3.563,P=0.059）and the incidence of adverse drug response was 24.1%（75/311） and 13.8%（23/167）（χ2=7.132,P=0.009）repsectively for TB/HIV patients from HIV institutions and TB institutions.Conclusion We should intensify TB case finding in people living with HIV/AIDS.Meanwhile,HIV testing in TB patient is also an important measure.
出处
《中国防痨杂志》
CAS
2012年第12期768-772,共5页
Chinese Journal of Antituberculosis
关键词
结核
肺
药物疗法
治疗结果
HIV感染
重叠感染
Tuberculosis
pulmonary/drug therapy
Treatment outcome
HIV infections
Superinfection
