摘要
目的 探讨葛根黄豆苷元（ＤＺ）对脑缺血的保护作用及其作用机制。方法 小鼠断颅法、双侧颈总动脉不完全和完全结扎法，取脑组织测定乳酸和超氧化物歧化酶（ＳＯＤ）含量。结果 ＤＺ能够改善小鼠脑缺血后症状，延长断头小鼠喘气时间及双侧颈总动脉结扎小鼠的存活时间，并能够抑制缺血所致脑组织中乳酸和ＳＯＤ含量的改变。结论 ＤＺ对脑缺血具有保护作用，其作用机制与减少乳酸蓄积和清除自由基有关。
AIM To investigate the protective effect of daidzeid (DZ) on cerebral ischemia and it mechanism in mice METHODS Cerebral ischemia was induced by cutting heads and bilateral carotid arteries were completely or incompletely ligated RESULTS The stroke index score in ischemic mice was reduced by DZ, an the persistent time of gasping of mice by decapitation and survival time of mice by bilateral carotid arteries ligation were prolonged by DZ DZ could reduce the content of brain lactic acid while improve the brain superoxide dismutase activity CONCLUSIONS The results indicate that DZ has the protectiveeffect on cerebral ischemia injury Its mechanism may be related with its effect of decreasing of lactic acid content and reducing of free radicals production
出处
《中国药理学通报》
CAS
CSCD
北大核心
1999年第6期534-536,共3页
Chinese Pharmacological Bulletin
