摘要
给雄性ＳＤ大鼠饮用含氟化钠（１５０ｍｇ／Ｌ）及同时分别加入不同浓度亚硒酸钠（０－５ 、２－０ 和４－０ｍｇ／Ｌ） 的饮水共１０周，观察氟及硒氟联合作用对大鼠尿氟排泄及肾脏损害的影响，以找出硒拮抗氟毒性的最佳水平。结果表明，氟暴露大鼠血清氟和尿氟水平明显升高，并引起肾脏病理、酶组织化学和超微结构显著异常。２－０ｍｇ／Ｌ 亚硒酸对尿氟排泄的促进作用，及氟致肾脏损害的拮抗作用最强，０－５ｍｇ／Ｌ时对氟致肾损害的拮抗作用较弱，而４－０ｍｇ／Ｌ 时似乎对肾脏产生了一定的毒性作用。因此，可以认为２－０ｍｇ／Ｌ亚硒酸钠是本实验条件下硒拮抗氟致肾损害的最佳浓度。
Five groups of SD male rats were provided with deionized drinking water containing 0 and 150mg/L NaF,and containing both 150mg/L NaF and 0.5,2.0 or 4.0mg/L Na 2SeO 3 respectively for 10 weeks,in order to observe the effects of different concentrations of selenite in drinking water on the urinary excretion of fluoride and renal damages induced by 150mg/L NaF,and find out the optimal level of selenite in drinking water against fluoride toxicity.The results showed that fluoride could cause the significant elevation of fluoride ion levels in serum and urine of rats exposed to fluoride in drinking water and the obvious renal damages in patholoyg,enzyme histochemistry and ultrastructure.2.0mg/L Na 2SeO 3 in drinking water induced the most obvious acceleration of fluoride excretion in urine and possessed the most significant antagonistic effects on the renal impairments induced by 150mg/L NaF,those of 0.5mg/L Na 2SeO 3 were not evident,whereas 4.0 mg/L Na 2SeO 3 appeared to be toxic to kidney.Thus it is concluded that 2.0mg/L Na 2SeO 3 is the optimal concentration for the antagonistic effect on renal impairments induced by 150mg/L NaF in drinking water.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2000年第1期25-27,共3页
Chinese Journal of Public Health
基金
国家教委科研基金
关键词
硒
氟
肾损害
Selenite Urinary fluoride Renal damage Optimal antagonism
