摘要
目的观察吡柔比星膀胱灌注预防膀胱肿瘤复发的有效性,并对其药理作用展开分析。方法以2009年5月至2011年4月在我院接受治疗的膀胱肿瘤术后患者85例为研究对象,进行随机分组。所有患者均于术后1周开始进行膀胱灌注。A组42例患者给予丝裂霉素膀胱灌注,B组43例患者给予吡柔比星膀胱灌注治疗。术后随访1年,观察两组患者复发率、死亡率和治疗期间膀胱刺激征发生率的差异。结果与A组相比较,B组复发率、死亡率均明显较低,有统计学差异(P<0.05)。两组治疗期间膀胱刺激征发生率比较,无统计学差异(P>0.05)。结论采用吡柔比星膀胱灌注预防膀胱肿瘤复发效果满意,可在今后的临床工作中加以应用。
Objective To observe the effect of intravesical instillation of pirarubicin for preventing the recurrence of bladder cancer, and analyze its pharmacological action. Methods 85 postoperative patients with bladder tumor surgery treated in our hospital from May 2011 to April 2009 were chosen as research object and randomly divided into two groups. All patients received the bladder filling one week after operation. Group A was treated by bladder instillation of mitomycin, group B received intravesical instillation of pirarubicin. One year later, the recurrent rate, mortality and the incidence of bladder stimulation during bladder irritation were observed. Results Compared with group A, the recurrence rate, mortality of group B were lower, with statistically significant difference （P 〈0.05）. Bladder stimulation syndrome incidence had no statistical difference （P 〉0.05）. Conclusions The intravesical instillation of pirarubicin for preventing the recurrence of bladder tumor has satisfactory results, which deserves application in clinic.
出处
《临床医学工程》
2012年第12期2140-2141,共2页
Clinical Medicine & Engineering
关键词
吡柔比星
膀胱灌注
膀胱肿瘤复发
药理作用
Pirarubicin
Intravesical instillation
Bladder tumor recurrence
Pharmacological effect
