摘要
目的探讨神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病（HIE）的临床疗效。方法将98例HIE患儿随机分为两组，对照组49例患儿在常规治疗的基础上加用纳洛酮治疗，观察组49例患儿则在对照组的基础上加用神经节苷脂治疗，比较两组临床疗效。结果观察组总有效率为93．88％，明显高于对照组的71．43％（P〈0．05）；治疗7d和14d后，观察组新生儿神经行为评分（NBNA）明显高于对照组（P〈0．05）。结论神经节苷脂联合纳洛酮治疗HIE患儿疗效确切，可明显改善患儿脑功能，无明显不良反应，值得临床大力推广应用。
Objective To investigate the clinical efficacy of combination therapy with ganglioside and naloxone for neonatal hypoxic-ischemic encephalopathy （ HIE ）. Methods 98 neonates with HIE were randomly assigned to receive naloxone in addition to conventional therapy （ 49 neonates, control group ）, or naloxone combined with ganglioside in addition to conventional treatment （ 49 neonates, study group ）. The clinical efficacy was compared between the two groups. Results The total effectiveness rate was significantly higher in the study group than in the control group （ 93.88% vs. 71.43%, P 〈 0.05 ）. Scores on the NBNA were significantly higher in the study group than in the control group on days 7 and 14（ P 〈 0.05 ）. Conclusions Combination therapy with ganglioside and aloxone can significantly improve brain function. It is efficacious and has no significant adverse reactions and thus is worth popularizing clinically.
出处
《国际医药卫生导报》
2012年第23期3419-3421,共3页
International Medicine and Health Guidance News
