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应深化对多糖包被的认识 被引量：2

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摘要 感染性休克是危重症患者主要死亡原因之一，而导致这种高病死率的病理生理学基础是微循环障碍所致的器官灌注不足。在其复杂的病理生理学过程中，内皮细胞的活化和功能障碍是导致微循环功能障碍的主要因素。
作者 马晓春 孙旖旎
机构地区 中国医科大学附属第一医院重症医学科
出处 《中华医学杂志》 CAS CSCD 北大核心 2012年第45期3172-3174,共3页 National Medical Journal of China
关键词 病理生理学基础 微循环功能障碍 包被 多糖 主要死亡原因 危重症患者 感染性休克 微循环障碍
分类号 R459.7 [医药卫生—急诊医学]
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参考文献10

  • 1Henrich M, Gruss M, Weigan MA. Sepsis-Induced Degradation of Endothelial glycocalix. Sci World J ,2010,10 : 917-923.
  • 2Lennon FE, Singleton PA. Hyaluronan regulation of vascular integrity. Am J Cardiovasc Dis, 2011,1:200-213.
  • 3Chappell D, Westphal M, Jacob M. The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness. Cur Opin Anaesthesiol, 2009, 22 : 155-162.
  • 4Chappell D, Jacob M, Hofmann-Kiefer K, et al. A rational approach to perioperative fluid management. Anesthesiology, 2008, 109:723-740.
  • 5Chappell D, Jacob M, Hofmann-Kiefer K , et al. Antithrombin reduces shedding of the endothelial glycocalyx following ischaemia/reperfusion. Cardiovascu Res ,2009,83:388-396.
  • 6Marechal X, Favory R, Joulin O, et al. Endothelial glycocalyx damage during endotoxemia coincides with microcirculatory dysfunction and vascular oxidative stress. Shock, 2008, 29 : 572- 576.
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  • 9Jacob M. The endothelial glycocalyx affords compatibility of Starling's principle and high cardiac interstitial albumin levels. Cardiovascu Res, 2007, 73: 575-586.Shock, 2008, 29:572- 576.
  • 10Jianjie Wang, Susan Bingaman, Huxley VH. Intrinsic sex-specific differences in microvascular endothelial cell phosphodiesterases. Am J Physiol Heart Circ Physiol, 2010, 298:1146-1154.

同被引文献20

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引证文献2

二级引证文献7

中华医学杂志
2012年 第45期

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