摘要
目的:探讨不同严重度阻塞性睡眠呼吸暂停低通气综合征(OSAHS)女性患者血压的影响因素。方法:将190例2009至2011年就诊于上海交通大学医学院附属瑞金医院睡眠中心的女性打鼾患者按睡眠呼吸暂停低通气指数(AHI)分成4组:非OSAHS组、轻度OSAHS组、中度OSAHS组和重度OSAHS组,比较这4组患者的一般特征、多导睡眠图(PSG)监测指标及血压的差异,并分析不同OSAHS严重度组血压影响因素。结果:非OSAHS组43例,轻度OSAHS组52例,中度OSAHS组30例,重度OSAHS组65例。随着AHI升高,各组血压值呈升高趋势。各组血压比较,重度OSAHS组收缩压与非OSAHS组比较有显著差异(P<0.05);重度OSAHS组舒张压高于非OSAHS组及轻度OSAHS组(P<0.05)。多元回归分析显示轻度OSAHS患者收缩压与年龄及夜间最低脉搏血氧饱和度(SpO2)相关(P=0.038;P=0.028);舒张压与夜间最低SpO2相关(P=0.013)。中度OSAHS患者收缩压与年龄及AHI相关(P=0.013;P=0.002);舒张压与AHI相关(P=0.006)。重度OSAHS患者收缩压和舒张压主要与AHI相关(P=0.015;P=0.012)。结论:随着OSAHS严重度的增加,女性OSAHS患者的血压值逐渐升高,并且舒张压升高更明显。不同严重度女性OSAHS患者的血压影响因素各异。
Objective To analyze the blood pressure influencing factors in women with different degree of obstructive sleep apnea hypopnea syndrome （OSAHS） . Methods One hundred and ninety snoring women admitted in sleep medicine center of Ruijin hospital from January 2009 to January 2011 were analyzed retrospectively. These patients were divided into four groups by apnea hypopnea index （AHI）： mild; moderate; severe OSAHS and non-OSAHS groups. Parameters including age, neck circumference, body mass index （BMI）, Epworth score; polysomnography （PSG） features and blood pressure were compared between these groups. Correlations between blood pressure and biological characteristics, PSG inexes were analyzed. Results There were 43 non-OSAHS, 52 mild, 30 moderate and 65 severe OSAHS patients. Blood pressure elevated with increase in AHI. Inter-group comparison showed that there was significant difference in systolic blood pressure （SBP） between severe OSAHS group and non-OSAHS groups （P 〈0.05）, diastolic blood pressure （DBP） of severe OSAHS group was significantly higher than that of non-OSAHS group and mild OSAHS group （P 〈0.05）. Multiple regression analysis showed that SBP of mild OSAHS patients was correlated with age and lowest saturation of peripheral oxygen （SpO2） （P =0.038, P =0.028 respectively）, while DBP was correlated with lowest SpO2 （P =0.013）. In moderate OSAHS group, SBP was found to be correlated with age and AHI （P =0.013, P =0.002 respectively）, DBP was found to be correlated with AHI （P =0.006）. In severe OSAHS group, both SBP and DBP were found to be correlated with AHI （P = 0.015, P =0.012 respectively）. Conclusions With the increase in OSAHS severity, blood pressure of female OSAHS patients gradually increased, and the elevation of DBP was more significant. Blood pressure influencing factor differed withthe different severity of OSAHS in female patients.
出处
《内科理论与实践》
2012年第6期439-442,共4页
Journal of Internal Medicine Concepts & Practice
基金
国家自然科学基金(项目编号:81070068)
