摘要
目的评价血管内皮细胞生长因子(VEGF)在结直肠癌组织中的表达及其意义。方法运用Meta分析方法对国内采用免疫组化法检测结直肠癌组织VEGF表达的研究进行分析,通过计算机检索万方数据库、清华同方全文数据库(CNKI)、重庆维普全文数据库,检索时间为1989年1月—2011年4月,以"血管内皮生长因子、VEGF、结直肠肿瘤、结直肠癌"为关键词进行全文检索。采用OR及其95%CI进行比较、合并OR检验统计量用Z表示。结果最终共纳入26篇符合条件的文献,病例组共1 647例,对照组共870例。Meta分析结果显示,病例组VEGF阳性表达率高于对照组〔OR=0.18,95%CI(0.13,0.23),P=0.00〕;敏感性分析结果显示,Meta分析结果稳定性较好。VEGF表达与Duke分期〔OR=1.68,95%CI(1.40,2.02),P=0.00〕、肿瘤浸润深度〔OR=1.48,95%CI(1.11,1.97),P=0.01〕、TNM分期〔OR=1.45,95%CI(1.03,2.05),P=0.03〕、淋巴结转移〔OR=0.65,95%CI(0.55,0.77),P=0.00〕、3年生存率〔OR=1.94,95%CI(1.25,3.02),P=0.00〕及5年生存率〔OR=1.42,95%CI(1.06,1.89),P=0.02〕密切相关,与性别〔OR=0.92,95%CI(0.73,1.14),P=0.43〕、年龄〔OR=0.99,95%CI(0.80,1.23),P=0.96〕及肿瘤直径〔OR=1.11,95%CI(0.80,1.54),P=0.53〕无关。结论现有的临床研究证据表明,VEGF在结直肠癌组织中高表达,VEGF高表达可能在结直肠癌的发生、发展、转移及预后中起重要作用,对结直肠癌的早期诊断、治疗和预防具有重要参考意义。
Objective To explore the expression and significance of VEGF in colorectal carcinoma. Methods Meta - analysis was performed among studies on the expression of VEGF in colorectal carcinoma tested by immunohistochemistry method in China. Documents published in China from January 1989 to April 2011 were retrieved through CNKI, VIP and Wanfang data- bases and the key words were＂ vascular endothelial growth factor, VEGF, colorectal tumor and colorectal carcinoma＂ . OR and 95% CI were used and test statistics were expressed by Z. Results 26 of the case - control studies were selected for this Meta - analysis, including 1 647 colorectal carcinoma cases and 870 controls. The results of Meta - analysis showed that the positive rate of the expression of VEGF of the case group was significantly higher than the control group [ OR = 0. 18, 95% CI （0. 13, 0. 23） , P = 0. 00 ] The sensitivity analysis showed that the results of Meta - analysis were of good stability. The results of sub- groups for Meta -analysis showed that the expression of VEGF was closely related to Duke classification [ OR = 1.68, 95% CI （1.40, 2. 02）, P=0.00], infiltration depth [OR = 1.48, 95%CI （1.11, 1.97）, P =0. 01], TNM classification [ OR = 1.45, 95%CI （1.03, 2.05）, P=0.03], lymph nodemetastases [OR=0.65, 95%CI （0.55, 0.77）, P=0.00], sur- vival rate of 3 years [OR=1.94, 95%CI （1.25, 3.02）, P=0. 00] and survival rate of 5 years [OR= 1.42, 95%CI （1.06, 1.89）, P=0. 02], but was not related to gender [OR =0.92, 95%CI （0.73, 1.14）, P=0.43], age [OR= 0.99, 95%CI （0.80, 1.23）, P =0.96] or tumor diameter [OR = 1.11, 95% CI （0.80, 1.54）, P = 0.53].Conclusion The evidences of the existing clinical researches show that the expression of VEGF in colorectal cancer is high. The high expression of VEGF may play an important role in the occurrence, development, metastasis and prognosis of colorectal car- cinoma, and it is of great significance for the early diagnosis, treatment and prevention of colorectal carcinoma.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第36期4205-4208,共4页
Chinese General Practice
基金
广西自然科学基金项目(桂科自0728178)
广西研究生教育创新计划资助项目(2010106001002M11)
广西壮族自治区卫生厅中医药科技专项课题(GZKZ10-030)
