摘要
目的调查常州地区10年来新生儿先天性甲状腺功能减退症(CH)发生情况。方法 2001—2010年对常州地区175 876例活产新生儿进行了CH的筛查,检测足跟血中促甲状腺激素(TSH)水平,阳性患儿均建立治疗随访档案。分析10年CH患儿检出率、近3年各季度CH误诊率、CH患儿足跟血TSH水平以及CH患儿的治疗情况及预后。结果 2001—2010年常州地区共开展新生儿疾病筛查175 876例,经阳性召回确诊CH患儿共83例,发病率为1/2 119。2001—2010年CH患儿检出率比较,差异无统计学意义(χ2=6.299,P=0.710)。2008—2010年各季度CH误诊率比较,差异无统计学意义(P>0.05)。75例CH患儿足跟血TSH水平10～50 mU/L,8例<10 mU/L,其中6例TSH<9 mU/L。确诊的83例CH患儿中,5例治疗中途失去联系,2例回老家治疗,2例拒绝治疗,其余均在本中心接受治疗,16例患儿经正规治疗2～3年后永久停药。治疗患儿中,无一例发生智力障碍,且身高和体质量均达到相应年龄标准。结论常州地区10年CH患儿检出率大致与全国平均水平持平,CH无明显季度变化;CH的早期筛查有助于早期发现、早期诊断及治疗,减少智力障碍的发生,促进患儿的预后。
Objective To investigate the data of congenital hypothyroidism （CH） in Changzhou city over the past ten years. Methods CH was screened among the 175 876 newborns from 2001 to 2010 in Changzhou city. The TSH level in heel blood was tested and following up documents were established for those who had positive results. The detection rate of CH newbo- rns, CH misdiaguosis rate over the past three years, TSH level in heel blood of CH newborns and the treatment and prognosis of CH newborns were all analyzed. Results A total of 175 876 newborns were screened from 2001 to 2010, among which 83 cases were confirmed with CH, and the incidence was 1/2 119. The CH detection rate between each year from 2001 to 2010 showed no statistically significant difference （ χ2 =6. 299, P =0. 710） . The CH misdiagnosis rate between each year from 2008 to 2010 also showed no statistically significant difference （P 〉 0. 05 ） . TSH level in 75 CH newborns was 10 - 50 mU/L, 8 CH newborns was 〈 10 mU/L and 6 newborns was 〈 9 mU/L. Of the 83 confirmed cases, 5 cases lost contact during treatment, 2 cases sought treatment in their hometowns, 2 cases refused to receive treatment and other cases received treatment in our center. 16 cases were withdrew drugs after 2 to 3 years regular treatment. Among the newborns underwent treatment, no case had mental retardation and their height and body weight both reached age standard. Conclusion The ten - year CH detection rate in Changzhou city is ap- proximately equal to that of the whole nation, and CH has no obvious difference between quarters. Early screening of CH is condu- cive to early detection, early diagnosis and treatment, and can reduce the incidence of mental retardation and improve prognosis.
出处
《中国全科医学》
CAS
CSCD
北大核心
2012年第36期4247-4249,共3页
Chinese General Practice
