摘要
目的:分析甲基泼尼松龙(甲泼尼龙)对儿童重症喘息性支气管炎的治疗效果。方法:取60例重症喘息性支气管炎患儿,随机分为甲泼尼龙组和地塞米松组,每组30例,甲泼尼龙组给予甲泼尼龙2 mg/(kg·8 h)静脉滴注,地塞米松组给予地塞米松0.5 mg/(kg·d)静脉滴注,两组均连用3 d,观察两组患儿临床症状、体征、经皮血氧饱和度及血气分析好转时间。对两组疗效对比采用秩和检验,计量资料组间差异比较采用t检验,P<0.05有统计学意义。结果:治疗24 h后甲泼尼龙组喘息性支气管炎患儿血气分析氧分压(PaO2)改善程度优于地塞米松组,P<0.05。治疗72 h后甲泼尼龙组哮喘儿童临床症状、体征恢复情况明显好于地塞米松组,P<0.05。结论:甲泼尼龙治疗儿童重症喘息性支气管炎效果好,可迅速缓解喘息症状,纠正缺氧,缩短病程,疗效确切,可以在临床上推广使用。
Objective To analyze the effect of methylprednisolone and dexamethasone in treating the severe children asth- ma. Method 60 children with severe asthmatic bronchitis in inpatient ward were divided into two groups averagely,30 children were treated with methylprednisolone, and 30 children were treated with dexamethasone, patients in methylprednisolone group were treated with methyl- prednisolone 2 miUigram/kg/8 h by intravenous drip, and patients in dexamethasone group were treated with dexamethasone 0. 5 milligram/ kg/d by intravenous drip for 3 or more days. To observe the clinical symptoms, objective signs, transcntaneous oxygen saturation, and blood gas analysis turnaround time in these two groups ,we compared the time that every index improved, we a nalyzed the detection results with the SPSS10. 0 statistics software, compared the curative effects between the two groups employing the rank - sum test, comparing the differ- ences of measurement data between the two groups employing test, P 〈 0. 05 Arethey means the difference was statistically signifi- cant. Results Duration of recovery of clinical symptoms, objective signs, blood gas analysis in methylpreduisolone group patients were all shorter than those in dexamethasoni group patients, P 〈 0. 05. Conclusion The effect of methylprednisolone on severe children asthmatic bronchitis is better than that of dexamethasone, it can control the episode of gasping and retrieve hypoxia quickly, shorten the course of desease, so it should be used widely in clinical practice for severe children asthmatic bronchitis.
出处
《吉林医学》
CAS
2012年第34期7415-7416,共2页
Jilin Medical Journal
