摘要
目的:了解临床常见革兰阴性杆菌的耐药性,指导临床合理使用抗菌药物。方法:对4 282例临床分离常见革兰阴性杆菌进行药敏试验,并用WHONET 5.4软件进行数据分析。结果:大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌、鲍氏不动杆菌、嗜麦芽寡养单胞菌的分离率分别为31.06%、26.53%、19.38%、14.29%、8.73%;大肠埃希菌、肺炎克雷伯菌对阿米卡星、亚胺培南、美罗培南的耐药率均≤20.00%,鲍氏不动杆菌、铜绿假单胞菌对亚胺培南、美罗培南的耐药率≤10.00%,对其他抗菌药物几乎在耐药率≥40.00%;嗜麦芽寡养单胞菌对米诺环素、磺胺甲噁唑/甲氧苄啶、左氧氟沙星的耐药率≤10.0%。结论:常见革兰阴性杆菌对抗菌药物的耐药率存在较大差异,临床医师应根据不同细菌及其药敏结果选择合适的抗菌药物进行治疗。
Objective To realize the drug resistance of the common clinical gram negative bacilli and instruct the proper clinical appli- cation of antibacterial. Method 4282 cases of clinical separated gram negative bacilli were conducted drug resistance experiments and had data analysis with WHONET 5. 4. Results The separate rate of E. coli was 31.06%, Klebisella pneumonia was 26. 53%, Pseudomonas aeruginosa was 19. 38%, A. baumannii was 14.29%, Stenotrophomonas mahophilia was 8.73%. The drug resistance of E. coli and Klebi- sella pneumoniae to amikacin, imipenem and Meropenem was less than or equal to 20. 00%, while A. baumannii and Pseudomonas aerugino- sa＇s drug resistance to imipenem and Meropenem was less than or equal to 10. 00%. To other antibacterials ,the drug resistance was equal to or over 40. 00%. The drug resistance of Stenotrophomonas mahophilia to minocycline, sulfalene, trimethoprim, Levofloxacin were less than or equal to 10. 0%. COnclusion There are great differences in the drug resistance of the common clinical gram negative bacilli. The clinical doctors should choose the proper antibacterial according to different bacteria and their drug resistance to treat.
出处
《吉林医学》
CAS
2012年第34期7427-7428,共2页
Jilin Medical Journal
关键词
革兰阴性杆菌
耐药性
药敏试验
Gram negative bacilli
Drug resistance
Drug resistance experiments
